Table 1.

Pathways and methods for brain delivery of drugs and diagnostics (Kopec et al. 2019)

1) Transcellular pathways	-Passive diffusion through cell membranes in the BBB
	-Receptor-mediated transport through the BBB
	-Liposome-mediated drug delivery
	-Nanoparticle delivery
	-Exome-mediated delivery
	-Viral vector delivery
2) Paracellular pathways	-Osmotic delivery (hypertonic solution to disrupt the tight junctions)
	-Disruption of protein-protein interactions to increase the porocity of the tight junctions by claudin and occluding peptides