Table 2.

Associations of the directly measured and derived plasma N-glycans with disease status, further adjusted for age and sex, and corrected for multiple testing

Glycan	Descriptiona	OR	95% CI	SE	p value
GP2	FA2B glycan	2.09	1.58, 2.76	0.30	1.16 × 10−5
GP4	FA2[6]G1 glycan	0.60	0.46, 0.79	0.08	2.16 × 10−3
GP5	FA2[3]G1 glycan	0.64	0.47, 0.86	0.10	1.32 × 10−2
GP7	M6 glycan	1.69	1.28, 2.24	0.24	2.01 × 10−3
GP10	FA2G2 glycan	0.57	0.43, 0.76	0.08	1.24 × 10−3
GP12	M7 glycan and A2G2S1 glycan	1.86	1.37, 2.53	0.29	1.15 × 10−3
GP17	FA2BG2S1 glycan	1.47	1.08, 2.00	0.23	5.04 × 10−2
GP21	A2G2S2 glycan	1.52	1.16, 1.98	0.21	8.56 × 10−3
GP22	FA2G2S2 glycan	1.74	1.32, 2.29	0.25	1.15 × 10−3
GP23	FA2BG2S2 glycan	1.66	1.23, 2.25	0.26	5.61 × 10−3
GP25	A3G3S2 glycan	2.12	1.56, 2.87	0.33	4.54 × 10−5
GP29	A3G3S3 glycan	1.62	1.20, 2.19	0.25	7.12 × 10−3
B	Structures with bisecting GlcNAc	1.72	1.26, 2.34	0.27	3.52 × 10−3
G1	Monogalactosylated structures	0.63	0.47, 0.84	0.09	7.01 × 10−3
HM	High-mannose structures	1.65	1.26, 2.16	0.23	2.16 × 10−3

Only statistically significant associations are presented; for all associations see electronic supplementary material [ESM], Table 9

^aThe description relates to the percentage of that glycan in total plasma N-glycans

GP, glycan peak. Structure abbreviations: all N-glycans have two core GlcNAcs; F at the start of the abbreviation indicates a core fucose α1,6-linked to the inner GlcNAc; Mx indicates the number of mannose residues on core GlcNAcs; Ax indicates the number of antenna (GlcNAc) on the trimannosyl core: A2, biantennary with both GlcNAcs β1,2-linked; A3, triantennary with a GlcNAc linked β1,2 to both mannose residues and the third GlcNAc linked β1,4 to the α1,3-linked mannose; B indicates bisecting GlcNAc linked β1,4 to β1,3-mannose; Gx indicates the number of β1,4-linked galactose residues on the antenna; Sx indicates the number of sialic acids linked to galactose