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. 2022 Feb 23;15:1237–1248. doi: 10.2147/JIR.S351660

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© 2022 Dai et al.

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The changing trend of cytokines and Treg/Th17 cells matched with the pathogenesis process of ATP-activated P2X7R-regulated acute gouty arthritis. (A) The trends of P2X7R and IL-1β in ATP group. (B) The trends of CD4⁺IL-17⁺Th17 cells and IL-17 in ATP group. (C) The trends of CD4⁺CD25⁺Foxp3⁺Treg cells and TGF-β₁ in ATP group. (D) The trends of CD4⁺CD25⁺Foxp3⁺Treg cells and CD4⁺IL-17⁺Th17 cells in ATP group. (E) The ratios of Treg/Th17 among ATP group, BBG group and Control group. * P<0.05, ATP group vs BBG group, # P<0.05, ATP group vs Control group.