Table 5.
Cumulative cancer mortality of second primary cancer (SPC) compared to first primary cancer (FPC) at 5 years, 10 years, and end of follow-up since diagnosis for different types of cancer.
| 5-year mortality (95% CI) (%) | 10-year mortality (95% CI) (%) | Overall mortality (95% CI) (%) | |
|---|---|---|---|
| BC + BC | 21.7 (20.9, 22.4) | 30.7 (29.6, 31.7) | 33.1 (31.4, 34.8) |
| Breast cancer | 12.1 (11.6, 12.7) | 17.0 (16.2, 17.8) | 20.0 (18.6, 21.3) |
| Absolute mortality differencea | 9.5 (8.6, 10.5) | 13.7 (12.8, 14.6) | 13.1 (11.0, 15.3) |
| BC + Lung cancer | 69.7 (68.3, 71.0) | 73.9 (72.3, 75.4) | 75.4 (73.2, 77.7) |
| Lung cancer | 67.9 (66.5, 69.3) | 71.5 (70.0, 73.0) | 72.7 (70.1, 75.3) |
| Absolute mortality difference | 1.8 (−0.2, 3.7) | 2.4 (0.4, 4.3) | 2.7 (−0.7, 6.1) |
| BC + Colorectal cancer | 33.7 (32.0, 35.4) | 40.2 (38.2, 42.1) | 40.6 (38.5, 42.6) |
| Colorectal cancer | 30.7 (29.1, 32.3) | 34.9 (33.1, 36.7) | 36.9 (34.3, 39.5) |
| Absolute mortality difference | 3.0 (0.7, 5.3) | 5.3 (3.0, 7.6) | 3.7 (0.4, 7.0) |
| BC + Uterine cancer | 27.1 (25.2, 29.0) | 32.3 (30.1, 34.6) | 36.3 (32.3, 40.3) |
| Uterine cancer | 18.9 (17.2, 20.5) | 20.7 (18.9, 22.5) | 21.2 (19.2, 23.1) |
| Absolute mortality difference | 8.2 (5.7, 10.7) | 11.6 (9.1, 14.1) | 15.1 (10.7, 19.5) |
| BC + Lymphoma | 36.4 (33.5, 39.2) | 43.3 (39.8, 46.7) | 47.8 (41.5, 54.0) |
| Lymphoma | 32.0 (29.3, 34.7) | 36.4 (33.2, 39.6) | 37.6 (33.7, 41.6) |
| Absolute mortality difference | 4.4 (0.4, 8.3) | 6.9 (2.9, 10.8) | 10.1 (2.7, 17.6) |
| BC + Thyroid cancer | 7.6 (6.1, 9.2) | 12.0 (9.4, 14.7) | 14.2 (10.1, 18.3) |
| Thyroid cancer | 2.3 (1.4, 3.2) | 3.3 (1.9, 4.7) | 4.2 (2.0, 6.4) |
| Absolute mortality difference | 5.3 (3.5, 7.1) | 8.7 (6.9, 10.5) | 10.0 (5.3, 14.6) |
| BC + Melanoma | 14.0 (11.9, 16.0) | 19.0 (16.3, 21.7) | 19.0 (16.3, 21.7) |
| Melanoma | 8.4 (6.7, 10.0) | 10.7 (8.6, 12.7) | 12.1 (8.7, 15.5) |
| Absolute mortality difference | 5.6 (2.9, 8.2) | 8.3 (5.6, 11.0) | 6.9 (2.5, 11.3) |
| BC + Ovarian cancer | 57.3 (54.2, 60.5) | 70.6 (67.2, 74.0) | 73.1 (69.3, 76.9) |
| Ovarian cancer | 55.1 (52.0, 58.2) | 64.6 (61.1, 68.1) | 66.2 (62.5, 69.8) |
| Absolute mortality difference | 2.3 (−2.1, 6.7) | 6.0 (1.6, 10.4) | 6.9 (1.7, 12.2) |
| BC + Pancreatic cancer | 89.6 (87.7, 91.5) | 89.8 (87.9, 91.7) | 92.4 (89.5, 95.3) |
| Pancreatic cancer | 88.7 (86.8, 90.7) | 89.7 (87.7, 91.6) | 89.7 (87.7, 91.6) |
| Absolute mortality difference | 0.9 (−1.9, 3.6) | 0.1 (−2.6, 2.8) | 2.7 (−0.8, 6.2) |
| BC + Leukemia | 59.9 (57.1, 62.7) | 63.9 (60.9, 67.0) | 66.7 (62.4, 71.0) |
| Leukemia | 44.4 (41.6, 47.3) | 50.7 (47.4, 53.9) | 52.4 (48.4, 56.5) |
| Absolute mortality difference | 15.4 (11.5, 19.4) | 13.2 (9.3, 17.2) | 14.2 (8.4, 20.1) |
FPC first primary cancer, SPC second primary cancer, CI confidence interval, BC breast cancer.
aAbsolute mortality difference = Mortality of SPC – Mortality of FPC.