Table 3.
Univariate analysis of logistic regression of risk factors for IgG4-RD patients complicated with AR or CRS (Case group).
| Characteristics | Univariate analysis | ||
|---|---|---|---|
| P-valuea | OR | 95%CI | |
| Demographics | |||
| Age at disease onset, median (IQRb) | 0.438 | 0.996 | 0.985, 1.006 |
| Age at diagnosis, median (IQR) | 0.507 | 1.004 | 0.993, 1.014 |
| Disease duration, months, median (IQR) | 0.011* | 1.006 | 1.001, 1.010 |
| Female, n (%) | 0.684 | 0.941 | 0.704, 1.259 |
| Clinical features | |||
| Other types of allergic disease, n (%) | 0.001* | 5.093 | 3.389, 7.655 |
| Organ involvement, n (%) | |||
| ≥ 3 organs | 0.001* | 3.827 | 2.823, 5.189 |
| Lymph node | 0.001* | 2.856 | 2.058, 3.962 |
| Thyroid gland | 0.040* | 2.011 | 1.032, 3.919 |
| Lung | 0.001* | 3.071 | 2.073, 4.548 |
| Kidney | 0.214 | 1.315 | 0.853, 2.027 |
| Liver | 0.328 | 1.512 | 0.660, 3.466 |
| Pancreas | 0.202 | 1.237 | 0.892, 1.713 |
| Biliary system | 0.027* | 1.672 | 1.060, 2.636 |
| Gallbladder | 0.017* | 2.013 | 1.134, 3.573 |
| Retroperitoneal fibrosis | 0.916 | 0.979 | 0.657, 1.458 |
| Mesentery | 0.548 | 1.686 | 0.307, 9.258 |
| Aorta | 0.076 | 2.785 | 0.900, 8.620 |
| Prostate | 0.736 | 1.125 | 0.567, 2.233 |
| Salivary gland | 0.001* | 2.347 | 1.751, 3.146 |
| Lacrimal gland | 0.001* | 3.272 | 2.396, 4.467 |
| Parotid gland | 0.001* | 2.329 | 1.665, 3.258 |
| Laboratory examinations | |||
| Serum IgG4 (mg/dL), median (IQR) | 0.001* | 1.000 | 1.000, 1.001 |
| Serum IgG4 (mg/dL)/IgG (mg/dL), median (IQR) | 0.001* | 8.545 | 2.804, 26.036 |
| Serum IgE (IU/ml), median (IQR) | 0.001* | 1.002 | 1.001, 1.002 |
| CRP (mg/dl), median (IQR) | 0.428 | 1.004 | 0.994, 1.015 |
| ESR (mm/h), median (IQR) | 0.001* | 1.024 | 1.003, 1.045 |
| Eosinophilia, n (%) | 0.001* | 4.509 | 2.068, 9.831 |
| ANA (+), n (%) | 0.115 | 0.639 | 0.366, 1.115 |
| RF (+), n (%) | 0.937 | 1.024 | 0.573, 1.828 |
| Hypocomplementemia, n (%) | 0.018* | 1.754 | 1.100, 2.796 |
a*means P-value < 0.05; bIQR, interquartile range.