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. 2022 Jul 14;12:11984. doi: 10.1038/s41598-022-16017-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RNA-seq analysis for CaCl₂-induced AAA samples of AMO-administered miR-33b KI mice and anti-miR-33b working hypothesis. (a) MA plot illustrating the number of differentially expressed genes. Red dots: upregulated genes; blue dots: downregulated genes, as determined by log₂(fold change) between anti-miR-33b and control AmNA administered CaCl₂-induced AAA samples of miR-33b KI mice. (b) Heatmap representation of normalized gene expressions as intensity-based Z-score. (c) Enrichment analyses of integrated pathways for anti-miR-33b injected AAA miR-33b KI mice. (d) Schematic diagram of the effects of anti-miR-33b.

RNA-seq analysis for CaCl₂-induced AAA samples of AMO-administered miR-33b KI mice and anti-miR-33b working hypothesis. (a) MA plot illustrating the number of differentially expressed genes. Red dots: upregulated genes; blue dots: downregulated genes, as determined by log₂(fold change) between anti-miR-33b and control AmNA administered CaCl₂-induced AAA samples of miR-33b KI mice. (b) Heatmap representation of normalized gene expressions as intensity-based Z-score. (c) Enrichment analyses of integrated pathways for anti-miR-33b injected AAA miR-33b KI mice. (d) Schematic diagram of the effects of anti-miR-33b.