Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 14;5:697. doi: 10.1038/s42003-022-03654-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — Representative IHC images of STEM121 levels at low magnification (a) and higher magnification (b) from three independent tumors from each of the vehicle control, pacritinib, selumetinib, and combination pacritinib + selumetinib treatment groups. Scale bars: 1500 μm (a) and 600 μm (b). c ImageJ quantification of UI226 tumor area from STEM121 stained slides representing the vehicle control (N = 4), pacritinib (N = 3), selumetinib (N = 4), and combination pacritinib + selumetinib (N = 4) treatment groups. Results were analyzed using ANOVA and a Dunnett’s test for multiple comparisons. Error bars: SEM. p < 0.05*. vehicle vs pac/sel, p = 0.0105. d Representative MRI images from three independent RCMB18 tumors representing the vehicle control, pacritinib, selumetinib, and combination pacritinib + selumetinib treatment groups. Arrows denote individual or multiple tumor lobes in representative images from each treatment group. e ImageJ quantification of RCMB18 tumor volume from compiled MRI images representing the vehicle control (N = 3), pacritinib (N = 3), selumetinib (N = 3), and combination pacritinib + selumetinib (N = 3) treatment groups. Results were analyzed using ANOVA and a Dunnett’s test for multiple comparisons. Error bars: SEM. p < 0.05*. vehicle vs pac/sel, p = 0.0308.