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. 2022 Jul 1;12:791867. doi: 10.3389/fonc.2022.791867

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Copyright © 2022 Guo, Qian, Yu, Bi, Jiao, Jiang, Yu, Wu, Shi and Kong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the risk score formula for relapse prediction in the TCGA cohort. (A) Scatter plot for the distribution of risk score and relapse status of individual patients. (B) Survival status of CCA patients in the two 8-IRDEGs signature subgroups. (C) The Kaplan–Meier survival curve of recurrence-free for patients between two different groups. (D) Time-dependent ROC curve at 1, 3, and 5 years. (E) Comparison of prognostic accuracy between the signature and single mRNAs. (F) Comparison of prognostic accuracy between the signature and clinical characteristics. p-values were calculated using the log-rank test. HR, hazard ratio; AUC, area under the ROC curve; RFS, recurrence-free survival.