Table 4.
Test–retest reliability for HCMSQ
| Domain | Correlation between HCMSQ scores at baseline (test) and W6 (retest) in patients reporting the same global impression of symptoms on the PGIC and PGIS | Correlation between scores at W1 (test) and W2 (retest) in patients with no change in clinical status during screening | ||||
|---|---|---|---|---|---|---|
| ICC-Baseline_W6 (PGIC) | ICC-Baseline_W6 (PGIS) | ICC-Screening_W1_W2 | ||||
| N | Correlation | N | Correlation | N | Correlation | |
| MAVERICK-HCM trial data set | ||||||
| Cardiovascular symptoms | 11 | 0.829 | 15 | 0.746 | 33 | 0.754 |
| Tiredness | 11 | 0.862 | 15 | 0.815 | 33 | 0.807 |
| Shortness of breath | 11 | 0.841 | 15 | 0.753 | 33 | 0.814 |
| Total score | 11 | 0.865 | 15 | 0.796 | 33 | 0.762 |
| EXPLORER-HCM trial data set | ||||||
| Cardiovascular symptoms | – | – | – | – | 194 | 0.888 |
| Tiredness | – | – | – | – | 194 | 0.827 |
| Shortness of breath | – | – | – | – | 194 | 0.844 |
| Total score | – | – | – | – | 194 | 0.886 |
HCM hypertrophic cardiomyopathy, HCMSQ Hypertrophic Cardiomyopathy Symptom Questionnaire, ICC intraclass correlation coefficient, PGIC Patient Global Impression of Change, PGIS Patient Global Impression of Severity, W week