Table 5.

Incremental costs associated with acute and chronic complications (with vs. without)

	Cost difference
	Minimum	Maximum
Acute (per admission)
Stroke [42, 43]  Myocardial infarction [42]  Acute chest syndrome [42]  Vaso-occlusive crisis [38, 39, 42, 48]  Acute kidney injury [42]  Depression [44]	$56,316 [43] $53,458 $26,299 $5335 [48] $8205 $2616	$93,868 [42] – – $13,944 [39] – –
Chronic (PPPY)
Stroke year [43]  End-stage renal disease [43]  Pulmonary hypertension [42, 43]  Chronic kidney disease [43]  Post stroke year [42, 43]  Vaso-occlusive crisis [47, 48]  Heart failure [42]  Nephrotoxicity [42]  Opioid dependence [42]  Neurocognitive impairment [42]  Fatigue [42]	$230,066 $152,033 $19,343 [42] $77,019 $9807 [42] $4609 [48] $32,505 $20,708 $17,345 $11,687 $4398	– – $89,930 [43] – $68,772 [43] $45,155 [47] – – – – –

All costs were adjusted to 2019 US$ using the Consumer Price Index. For additional details and study-specific adjustments, see Appendix Table B2

PPPY per patient per year