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. 2022 Jul 1;13:924080. doi: 10.3389/fneur.2022.924080

Figure 3.

Figure 3

AQP4 and GFAP fluorescence maps among different groups in the dorsal cortex. (A) Schematic diagram of the dorsal cortex along with representative immunofluorescence maps, Scale bar, 100 μm; (B) Statistical plots of AQP4 mean fluorescence intensity, GFAP mean fluorescence intensity, and polarity of AQP4 in the dorsal cortex of different groups of mice. Compared with the sham group, the mean fluorescence intensity of AQP4 did not change significantly at 6 h but increased significantly at 1, 3, and 7 days (P = 0.9999, P = 0.0007, P < 0.0001, P < 0.0001; n = 8–24/group). Compared with the sham group, the mean fluorescence intensity of GFAP did not change significantly at 6 h but increased significantly at 1, 3 and 7 days (P = 0.9942, P < 0.0001, P < 0.0001, P < 0.0001; n = 8–24/group). The polarity of AQP4 decreased significantly at 6 h, 1, 3, and 7 days compared with the sham group (P = 0.0086, P < 0.0001, P < 0.0001, P < 0.0001; n = 5–6/group). **P < 0.01, ***P < 0.001; ns, not statistically significant. One-way ANOVA, Tukey's post-hoc test.