Table 5.

Logistic regression of irAEs.

		irAEs (P-value)		Severe irAEs (P-value)
		Univariate	Multivariate	Univariate
Sex	Male/female	0.110	0.579	0.492
Age	<60/≥60	0.229		0.138
Histology	Non-squamous/squamous	0.765		0.188
Line of therapy	First/second/third and beyond	0.191	0.412	0.779
Combined chemotherapy	No/yes	0.603		0.500
Smoking status	No/yes	0.170	0.750	0.586
Drinking status	No/yes	0.534		0.977
ECOG PS	0/1/2–4	0.453		0.529
Total lymphocyte	×106	0.090	0.229	0.536
B cell	×106	0.332		0.925
T cell	×106	0.120	0.017	0.502
NK cell	×106	0.410		0.870
CD4+ T	×106	0.050	0.123	0.552
CD8+ T	×106	0.777		0.607
CD4+CD45RA− T	×106	0.213		0.415
CD4+CD45RA+ T	×106	0.009	0.206	0.911
CD4+CD28+ T	×106	0.101	0.599	0.747
CD8+CD28+ T	×106	0.678		0.540
CD8+DR+ T	×106	0.538		0.699
CD8+CD38+ T	×106	0.036	0.011	0.050
CD4+ T/lymphocyte	×100%	0.905		0.491
CD8+ T/lymphocyte	×100%	0.219		0.924