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. 2022 Jul 1;16:100345. doi: 10.1016/j.mtbio.2022.100345

Fig. 12.

Fig. 12

Virus-infected kidney organoids. (A) Histological images of periodic acid-Schiff (PAS)-, SV40 T antigen (early gene of BK virus)- and VP-1 (late gene of BK virus)-stained BK virus-infected tubuloids at 10 days post-infection. Black arrows indicate larger blue nuclei (intracellular basophilic viral inclusions) [152]. (B) Kidney organoids without any treatment (R, mock-infected) or with treatment using SB431542 (S), SARS-CoV-2 (T) and SARS-CoV-2 + SB431542 (U). Scale bar, 20 μm [154]. (C) Effect of human recombinant soluble ACE2 (hrsACE2) on SARS-CoV-2-infected kidney organoids [155].