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. 2022 Jul 1;16:100345. doi: 10.1016/j.mtbio.2022.100345

Fig. 4.

Fig. 4

Symbiotic bacteria-co-cultured small intestinal organoids. (A) Time-lapse images of immature and mature organoids after microinjection with red fluorescence protein (RFP)-expressing L. plantarum. Scale bar, 200 μm [72]. (B) Immunofluorescence images of control (Ctrl), L. reuteri D8 (D8)-infected and heat killed D8 (HK-D8) organoids with (top) or without (bottom) the treatment of TNF-α [73]. (C) Histological images of periodic acid-Schiff (PAS)- and Alcian blue-stained organoids microinjected with E. coli [74].