Table 2.
COS and clinical outcomes of PCOS patients in four body weight groups (n = 409).
| Characteristics | Weight 40~50kg Group | Weight 50~60 kg Group | Weight 60~70 kg Group | Weight ≥70 kg Group | P | |
|---|---|---|---|---|---|---|
| (n = 63) | (n =188) | (n = 109) | (n = 49) | |||
| Initial Gn dosage (IU/day) | 150 (125-150) | 150 (150-184.4)ab | 175 (150-225)cd | 212.5 (175-300)ef | <0.001* | |
| Stimulation time (days) | 9 (8.5-10) | 10 (9-11) | 10 (9.3-11)c | 10 (9-12)e | <0.001* | |
| Total dosage of Gn (IU) | 1350 (1125-1512.5) | 1575 (1350-1846.9)ab | 1775 (1500-2250)cd | 2137.5 (1800-2587.5)ef | <0.001* | |
| Number of oocytes with diameter ≥14mm on hCG day | 12 (8-13.5) | 10 (7-13) | 9 (8-11.8)c | 8 (7-9.3)e | 0.009* | |
| E2 on hCG day (pg/ml) | 5200.3 (3470.2-8891.9) | 5128.2 (3249.8-7094) | 4254.8 (2776.2-6748.7) | 2786.5 (1989-3793.9)ef | <0.001* | |
| P on hCG day (ng/ml) | 1.2 (0.8-1.4) | 1 (0.8-1.5) | 0.9 (0.6-1.3) | 0.7 (0.5-1.1)ef | 0.009* | |
| LH on hCG day (IU/L) | 1.7 (1.1-3.1) | 1.7 (0.9-3.5) | 2.1 (1.1-3.2) | 2.4 (1.2-3.1)e | 0.012* | |
| Endometrial thickness on hCG day (mm) | 5 (4.5-5.6) | 5 (4.2-5.6) | 5 (4.4-5.5) | 5 (4.2-5.4) | 0.283 | |
| Ovarian response | High | 65.08% (41/63) | 64.89% (122/188) | 60.55% (66/109) | 40.82% (20/49)gh | 0.018* |
| Normal | 34.92% (22/63) | 35.11% (66/188) | 39.45% (43/109) | 59.18% (29/49) | ||
| Number of oocytes retrieved | 13 (9.5-20) | 16 (11-21.8) | 15 (10-20) | 12 (9.8-16.3) | 0.06 | |
| MII oocyte rate | 83.66% (814/973) | 84.52% (2729/3229) | 84.78% (1521/1794) | 86.69% (573/661) | 0.405 | |
| IVF fertilization rate | 74.86% (658/879) | 74.14% (2340/3156) | 72.73% (1264/1738) | 78.23% (485/620) | 0.06 | |
| IVF normal fertilization rate | 60.87% (574/943) | 60.15% (1923/3197) | 58.94% (1035/1756) | 58.85% (389/661) | 0.706 | |
| ICSI fertilization rate | 85.95% (104/121) | 91.60% (218/238) | 87.10% (162/186) | 88.68% (47/53) | 0.334 | |
| ICSI normal fertilization rate | 79.34% (96/121) | 87.17% (197/226) | 79.03% (147/186) | 81.13% (43/53) | 0.119 | |
| Cleavage rate | 97.64% (744/762) | 98.28% (2514/2558) | 98.60% (1406/1426) | 98.50% (524/532) | 0.411 | |
| Good-quality D3 embryo rate | 55.96% (310/554) | 52.54% (952/1812) | 51.15% (512/1001) | 53.74% (201/374) | 0.322 | |
| Blastocyst formation rate | 76.71% (326/425) | 73.17% (982/1342) | 72.60% (583/803) i | 63.94% (172/269)gh | 0.003* | |
| Good-quality blastocyst rate | 27.21% (83/305) | 35.40% (314/887)j | 29.66% (159/536) | 35.95% (55/153)g | 0.018* | |
| Fresh ET cancellation rate | 76.19% (48/63) | 66.49% (125/188) | 70.64% (77/109) | 53.06% (26/49) | 0.06 | |
| Severe OHSS rate | 4.76% (3/63) | 3.19% (6/188) | 1.83% (2/109) | 2.04% (1/49) | 0.753 | |
| Clinical pregnancy rate after fresh ET | 66.67% (10/15) | 50.79% (32/63) | 50.00% (16/32) | 52.17% (12/23) | 0.715 | |
| Cumulative clinical pregnancy rate | 64.10% (25/39) | 53.85% (70/130) | 57.58% (38/66) | 60.00% (18/30) | 0.694 | |
Gn, gonadotrophin; E2, estradiol; P, progesterone; LH, luteinizing hormone; OSI, ovarian sensitivity index; MII, mature; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; ET, embryo transfer; OHSS, ovarian hyperstimulation syndrome. *P values < 0.05; ap<0.05 between Group A and Group B; bp < 0.05 between Group B and Group C; cp < 0.05 between Group A and Group C; dp < 0.05 between Group C and Group D; ep < 0.05 between Group A and Group D; fp < 0.05 between Group B and Group D; gp < 0.0125 between Group A and Group D; hp < 0.0125 between Group B and Group D; ip < 0.0125 between Group C and Group D; jp < 0.0125 between Group A and Group B.