Table 2.
Treatment strategies and outcomes in infliximab treated ICI-induced myocarditis patients.
| Patient | Treatment strategy | Dosage | Time interval | Follow-up | irAE improvement | CV mortality | All-cause mortality |
|---|---|---|---|---|---|---|---|
| 1 | IV methylprednisolone 1 mg/kg for 4 days and infliximab | 5mg/kg | 0 day | In-hospital | N | Y | Y |
| 2 | Methylprednisolone 5mg/kg/d, plasmapheresis, IVIG 1g/kg D4, infliximab D6, D27, D39 | 5mg/kg | 2 days | 5+ months | Y | N | N |
| 3 | IV methylprednisolone 1g for 3 days, prednisone 80 mg twice daily for 5 days, 2 infliximab infusions after recurrence | N/A | N/A | 4+ months | Y | N | N |
| 4 | Methylprednisone 200mg on D1, then 1000mg daily for 3 days, infliximab and IVIG D4 after progression | 5mg/kg | 3 days | D18 | N | Y | Y |
| 5 | Methylprednisolone 500 mg iv twice daily 5 days, infliximab 2 infusions | 10mg/kg | 0 day | 1 week | N | Y | Y |
| 6 | IV methylprednisolone 1 mg/kg twice daily with mild response, then infliximab followed by 12 rounds of plasmapheresis, and subsequent IVIG | N/A | A few days | 19 months | Y | N | Y |
| 7 | 50 mg prednisone for 1 month then progressed, 1g methylprednisolone for 3 days but recurred upon tapering, then infliximab | 5mg/kg | 3 days | 9+ months | Y | N | N |
| 8 | IV methylprednisolone 1mg/kg worsened, then 2g methylprednisolone for 3 days and 1 dose of infliximab | 5mg/kg | N/A | 2 months | Y | N | Y |
| 9 | Prednisone 40mg D1-4, methylprednisolone 125mg D5-6, 1g D7, then infliximab D9 | 5mg/kg | 9 days | 15 days | N | Y | Y |
| 10 | Pulse dose steroids, then infliximab | 5mg/kg | 3 days | 1 year | Y | N | N |
| 11 | Pulse dose steroids, then infliximab | 5mg/kg | 3 days | 3 months | N/A | N | Y |
| 12 | Pulse dose steroids, then infliximab | 5mg/kg | 1 year | 1 year | Y | N | N |
| 13 | Pulse dose steroids, then infliximab | 5mg/kg | 3 days | 3 months | N/A | N | Y |
| 14 | High-dose glucocorticoids (1-2 mg/kg) then infliximab | N/A | N/A | 5 days | N/A | N/A | Y |
| 15 | High-dose glucocorticoids (1-2 mg/kg) then infliximab | N/A | N/A | In-hospital | N/A | N | N |
| 16 | High-dose glucocorticoids (1-2 mg/kg) then infliximab | N/A | N/A | In-hospital | N/A | N | N |
| 17 | High-dose glucocorticoids (1-2 mg/kg) then infliximab | N/A | N/A | 26 days | N/A | N/A | Y |
| 18 | IV prednisolone: D34-36 80mg; Methylprednisolone: D37-39 1000mg; D40-44 80mg; Infliximab: D40/D54 425mg | 5mg/kg | 6 days | 1 month | Y | N | N |
IV, intravenous; IVIG, intravenous immune globulin; N/A, not applicable.