Table 2.
Stratified analysis of the breast cancer risk in patients with primary Sjögren’s syndrome.
| Subgroups | No. of Studies | SIR (95%CI) | P Z | Heterogeneity (I 2, PH ) | Effects model | Meta-regression (P interaction)* |
|---|---|---|---|---|---|---|
| Gender | 0.355 | |||||
| Female | 7 | 0.93 (0.67-1.28) | 0.656 | 83.1%, <0.001 | Random | |
| Unspecific | 3 | 1.29 (1.08-1.55) | 0.006 | 21.8%, 0.278 | Fixed | |
| Matched/adjusted confounder | 0.696 | |||||
| Age, sex | 4 | 1.39 (0.91-2.13) | 0.129 | 52.2%, 0.099 | Random | |
| More than age and sex | 4 | 0.66 (0.46-0.96) | 0.028 | 79.8%, 0.002 | Random | |
| Median/mean age | 0.289 | |||||
| <60 years | 5 | 1.29 (0.84-1.98) | 0.239 | 50.5%, 0.088 | Random | |
| ≥60 years | 2 | 0.75 (0.49-1.17) | 0.208 | 90.8%, <0.001 | Random | |
| Study design | 0.246 | |||||
| Population-based | 5 | 0.81 (0.57-1.15) | 0.236 | 88.9%, <0.001 | Random | |
| Hospital-based | 3 | 1.68 (0.57-5.01) | 0.348 | 61.1%, 0.076 | Random | |
| Region | 0.078 | |||||
| Europe | 4 | 0.61 (0.51-0.73) | <0.001 | 5.7%, 0.364 | Fixed | |
| Asia | 2 | 1.32 (1.10-1.58) | 0.003 | 0.0%, 0.407 | Fixed | |
| Argentina | 1 | 3.76 (1.04–9.45) | 0.019 | NA | NA | |
| United States | 1 | 0.94 (0.79–1.11) | 0.476 | NA | NA | |
| Followed-up | 0.429 | |||||
| <6 years | 3 | 0.90 (0.60-1.37) | 0.633 | 93.3%, <0.001 | Random | |
| ≥6 years | 5 | 1.03 (0.51-2.11) | 0.927 | 73.8%, 0.004 | Random |
Bold indicates P values with statistical significance (<.05).
SIR, Standardized incidence ratios; NA, not applicable
*Multivariate meta-regression analysis for all the variables listed in this table.