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. 2022 Jul 1;13:901273. doi: 10.3389/fimmu.2022.901273

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Copyright © 2022 Bottomley, Harden, Wood, Hester and Issa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased mHLA-DRd is associated with subsequent malignancy development. (A) Receiver-operator characteristic (ROC) curve for prediction of malignancy in the year following mHLA-DRd quantification. Predictive performance is given [area under curve (AUC) and 95% confidence interval] as well as the optimal cut-off and corresponding sensitivity and specificity. (B) Kaplan-Meier curve demonstrating cumulative incidence of malignancy stratified by mHLA-DRd. (unadjusted and adjusted hazard ratios and P values are given in Table 3 ; log-rank test for difference between curves is provided in-plot).