TABLE 3.
PK parameters for asciminib in the ARA study
| Parameters | Asciminib (n = 23) | Asciminib + rabeprazole (n = 23) |
|---|---|---|
| AUCinf (ng*h/ml), G mean (GCV%) | 9850 (18.7) | 9710 (18.1) |
| AUClast (ng*h/ml), G mean (GCV%) | 9200 (18.5) | 9060 (17.9) |
| Cmax (ng/ml), G mean (GCV%) | 943 (27.4) | 856 (21.7) |
| Tmax (h), median (range) | 2.00 (1.00–4.00) | 2.00 (2.00–5.00) |
| t ½ (h), G mean (GCV%) | 12.6 (10.0) | 12.2 (10.1) |
| CL/F (L/h), G mean (GCV%) | 4.06 (18.7) | 4.12 (18.1) |
Abbreviations: ARA, acid‐reducing agent; AUC, area under the curve; AUCinf, AUC from zero to infinity; AUClast, AUC from zero to the last quantifiable concentration; CL/F, apparent plasma clearance; Cmax, maximum concentration of drug in plasma; GCV%, geometric coefficient of variation; G mean, geometric mean; PK, pharmacokinetic; t 1/2, terminal half‐life; Tmax, time to reach maximum concentration of drug in plasma.