FIGURE 3.

Effect of fibrates on cisplatin cytotoxicity using HK2 cells. Cell viability after 24 h of incubation in medium with or without 50 μM cisplatin was calculated as 100% for the vehicle group. (a, b) Fenofibrate (1, 10, 100 μM) a or bezafibrate (1, 10, 100 μM) b was administered simultaneously with cisplatin. (c) The 2 μM of GW6471, a PPARα inhibitor, was used. Values are expressed as mean ± SEM. Cis, cisplatin; Beza, bezafibrate; Feno, fenofibrate; GW, GW6471. ^† p < 0.05 versus vehicle, *p < 0.01 versus cisplatin, n = 8 in each group