TABLE 3.

Body weight, kidney weight, and renal function in vehicle‐treated mice and cisplatin‐treated mice with or without fenofibrate or bezafibrate

	Vehicle	Feno (300 mg/kg)	Beza (300 mg/kg)	Cisplatin	Cisplatin + Feno (30 mg/kg)	Cisplatin + Feno (100 mg/kg)	Cisplatin + Feno (300 mg/kg)	Cisplatin + Beza (30 mg/kg)	Cisplatin + Beza (100 mg/kg)	Cisplatin + Beza (300 mg/kg)
Initial body weight, g	24.4 ± 0.5	27.8 ± 0.5	24.4 ± 0.7	23.9 ± 0.5	26.3 ± 0.6	26.7 ± 0.5	26.8 ± 0.5	25.8 ± 0.5	25.4 ± 0.5	26.1 ± 0.6
Post body weight, g	24.5 ± 0.5	26.6 ± 0.5	23.1 ± 0.8	18.9 ± 0.2†	20.5 ± 0.7	20.9 ± 0.4	22.1 ± 0.8	22.2 ± 0.8	21.4 ± 0.8	21.3 ± 0.5
Kidney weight, mg	167.5 ± 8.4	170.8 ± 17.2	163.8 ± 6.9	140.0 ± 10.	154.4 ± 5.8	155.6 ± 3.9	164.3 ± 6.4	155.1 ± 6.0	164.3 ± 5.1	155.6 ± 4.8
Kidney weight/body weight, mg/g	6.86 ± 0.38	6.44 ± 0.73	7.11 ± 0.28	7.41 ± 0.49	7.54 ± 0.32	7.45 ± 0.23	7.45 ± 0.37	6.98 ± 0.17	7.73 ± 0.28	7.30 ± 0.14
Urine volume, ml	1.66 ± 0.15	1.67 ± 0.17	1.52 ± 0.20	0.74 ± 0.11†	0.43 ± 0.05	0.63 ± 0.08	0.81 ± 0.14	0.96 ± 0.12	0.89 ± 0.13	0.69 ± 0.10
BUN, mg/dl	19.2 ± 2.3	19.3 ± 1.0	23.4 ± 1.5	132.4 ± 13.2†	80.9 ± 5.8	66.4 ± 5.3*	43.3 ± 1.6**	79.2 ± 14.8	104.0 ± 28.7	83.5 ± 14.4
Ccr, ml/min/kg	11.59 ± 1.82	9.80 ± 1.53	8.67 ± 0.53	2.14 ± 0.36†	2.47 ± 0.30	3.75 ± 0.72	5.53 ± 0.57**	4.29 ± 0.51*	4.95 ± 0.59*	3.94 ± 0.43
BUN Ccr−1 ratio	2.2 ± 0.4	2.1 ± 0.3	2.7 ± 0.3	86.4 ± 25.9†	35.6 ± 6.2	22.2 ± 6.1*	8.5 ± 1.0**	26.4 ± 8.8*	23.1 ± 5.8*	22.8 ± 4.0*

Note: Data are presented as mean ± SEM. ^† p < 0.05 versus vehicle mice, *p < 0.05 and **p < 0.01 versus cisplatin mice. n = 4–9 in each group.

Abbreviations: Beza, bezafibrate; BUN, blood urea nitrogen; Ccr, creatinine clearance; Feno, fenofibrate.