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. 2022 Jul 1;13:886645. doi: 10.3389/fimmu.2022.886645

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Copyright © 2022 Bafor, Valencia and Young

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of naïve and activated DNT cells. The model summarizes and reflects how transitions impact naïve and activated DNT cells (Note- the literature indicates the possibility of several other DNT cell subsets). Importantly, DNT cells can modulate innate and adaptive immune cells based on immune-modulatory status or the prevailing condition in the tissue microenvironment. Ag = antigen. Figure created using Biorender.com.