Table 4.
No of patient (n = 2971) | No of event (n = 145) | Incidence rate per 10,000 person-years (95% CI) | 5-Year overall survival | 10-Year overall survival | p-value* | Unadjusted HR (95% CI) | p-value** | |
---|---|---|---|---|---|---|---|---|
Age at diagnosis of breast cancer | 0.0391 | |||||||
20-29 | 35 | 5 | 146.69 (61.06-352.44) | 91.43 (82.15-100.00) | 84.21 (71.34-97.08) | ref | ||
30-39 | 1123 | 87 | 129.06 (104.60-159.23) | 92.64 (90.96-94.33) | 88.80 (86.28-91.31) | 0.73 (0.30, 1.81) | 0.4988 | |
40-49 | 1740 | 52 | 89.80 (68.43-117.84) | 95.37 (93.97-96.77) | 93.49 (90.82-96.17) | 0.46 (0.18, 1.17) | 0.1024 | |
≥50 | 73 | 1 | 59.44 (8.37-422.00) | 97.50 (92.66-100.00) | Non-estimable | 0.30 (0.03, 2.55) | 0.2680 | |
Age at first delivery | 0.404 | |||||||
20-29 | 849 | 32 | 91.83 (64.94-129.85) | 94.95 (92.95-96.95) | 89.85 (84.92-94.78) | ref | ||
30-39 | 2021 | 107 | 119.37 (98.76-144.27) | 93.36 (91.99-94.73) | 90.41 (88.25-92.56) | 1.31 (0.88, 1.94) | 0.1850 | |
40-49 | 101 | 6 | 101.27 (45.50-225.42) | 96.80 (93.24-100.00) | 88.75 (79.04-98.47) | 1.13 (0.47, 2.69) | 0.7909 | |
Age at last delivery | 0.7965 | |||||||
20-29 | 439 | 19 | 94.77 (60.45-148.57) | 95.23 (92.96-97.49) | 92.30 (87.67-96.94) | ref | ||
30-39 | 2396 | 117 | 113.63 (94.80-136.20) | 93.66 (92.39-94.93) | 90.07 (87.83-92.30) | 1.16 (0.72, 1.89) | 0.5389 | |
40-49 | 136 | 9 | 121.73 (63.34-233.95) | 94.82 (90.75-98.90) | 87.61 (78.47-96.75) | 1.25 (0.57, 2.77) | 0.5768 | |
Number of delivery | 0.5631 | |||||||
1 | 1681 | 93 | 114.98 (93.83-140.89) | 93.65 (92.22-95.07) | 89.90 (87.54-92.27) | ref | ||
2 | 1194 | 47 | 102.35 (76.90-136.22) | 94.42 (92.64-96.20) | 91.01 (87.09-94.94) | 0.84 (0.59, 1.19) | 0.3220 | |
>=3 | 96 | 5 | 138.77 (57.76-333.40) | 94.05 (88.09-100.00) | 86.82 (72.13-100.00) | 1.13 (0.46, 2.78) | 0.7894 | |
Time-since-first-delivery | <.0001 | |||||||
< 5yr | 477 | 67 | 152.74 (120.21-194.06) | 89.73 (87.00-92.45) | 85.59 (82.37-88.80) | ref | ||
5yr-10yr | 1229 | 57 | 89.78 (69.25-116.39) | 95.26 (93.99-96.53) | Non-estimable | 0.44 (0.30, 0.64) | <.0001 | |
>=10yr | 1265 | 21 | 91.09 (59.39-139.70) | Non-estimable | Non-estimable | 0.42 (0.24, 0.71) | 0.0013 | |
Time-since-last delivery | <.0001 | |||||||
< 5yr | 759 | 87 | 143.17 (116.04-176.65) | 91.10 (89.06-93.13) | 87.16 (84.53-89.79) | ref | ||
5yr-10yr | 1508 | 46 | 79.86 (59.82-106.62) | 96.01 (94.80-97.23) | Non-estimable | 0.44 (0.30, 0.64) | <.0001 | |
>=10yr | 704 | 12 | 99.62 (56.58-175.42) | Non-estimable | Non-estimable | 0.53 (0.28, 1.01) | 0.0546 | |
Preeclampsia | 0.5516 | |||||||
No | 2920 | 141 | 110.44 (93.64-130.26) | 94.02 (92.93-95.11) | 90.33 (88.31-92.36) | ref | ||
Yes | 51 | 4 | 145.99 (54.79-388.97) | 91.55 (82.11-100.00) | 85.01 (69.87-100.00) | 1.35 (0.50, 3.65) | 0.5516 | |
Gestational DM | 0.5560 | |||||||
No | 2467 | 119 | 108.53 (90.68-129.89) | 94.10 (92.91-95.28) | 90.10 (87.87-92.33) | ref | ||
Yes | 504 | 26 | 125.20 (85.25-183.89) | 93.28 (90.55-96.02) | 91.48 (88.13-94.84) | 1.14 (0.74, 1.74) | 0.5562 |
*P-value by log rank test.
**P-value by Cox PH regression.