Table 4.

A detailed interaction of amino acid residues of spike glycoprotein- β-tocopherol complex and spike-RBD-ACE2 protein- β sitosterol in protein–ligand contact analysis

Protein–ligand contact analysis
S. no	Interaction	Spike glycoprotein- β-tocopherol complex	Spike-RBD-ACE2 protein- β sitosterol
1	H-bonds	A: Gln 1002, Gln 1005, Thr1006 B: Gln 1005 C: Thr1009	Ser 43, Ser44, Ser 47, Met62, Asn63, Asp 67, Lys74, Ser106, Asn121, Ala348, Glu375, His378, His505, Asn508
2	Hydrophobic	C: Phe 759, Leu763, Ala766, Gln1005, Val1008, Leu1012	Phe 32, Phe40, Met62, Trp69, Leu73, Ala99, Leu100, Ala348, Tyr385, Phe390, Leu391, Tyr510
3	Ionic
4	Water bridges	B: Gln 1005	Ser43, Ser47, Asn 51,Met62, Asn63, Asp 67, Ser70, Lys 74, Ser105, Ser106, Lys114, Asn117, Leu120, Asn121, Ser124, His345, Pro346, Thr347, Ala348, His374, Glu375, His378, Glu402, Glu406, His505, Asn508, Tyr510, Ser511, Tyr515