Figure 5.

Unsupervised clustering of malignant cells indicates tumor-associated features in addition to subtype-specific functions

(A and B) Unsupervised clustering of the malignant cell fraction plotted on the UMAP and color-coded according to cluster (A), tissue type, and dataset (B).

(C–E) The modified subtype score (C) and cell label defined in Figure 4E are projected on the UMAP. Violin plots showing the aggregation of subtype scores for each cluster (D).

(F) Enrichment analysis of differentially expressed genes in cell clusters using the KEGG database. Gene-Concept Network showing enriched terms of the KEGG database with nodes colored according to malignant cell clusters. The node size indicates the number of leaf nodes, and the characters show the Gene ID.

(G) Heatmap of the proportion of malignant cell clusters in each sample. The normal pancreas sample is highlighted in red.