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. 2022 Jul 1;13:833121. doi: 10.3389/fendo.2022.833121

Figure 1.

Figure 1

Maternal IL-1Ra treatment increased gain weight and reduced IL-1β released within the sera of GBS-infected dams. Comparison of mean maternal weight from G18 to G22 (A). Mean maternal serum concentration of IL-1β (B), CXCL1 (C) and, TNF-α (D) quantified by ELISA between CTL, GBS, and GBS plus IL-1Ra-exposed dams at 72 h post-GBS infection. Data were collected from three individual experiments. Analyses were performed between the experimental groups using Kruskal-Wallis test with Dunn’s multiple comparisons; *p < 0.05. Bars show mean ± SEM. Number (n) of dams: CTL (n = 6), GBS (n = 9), and GBS plus IL-1Ra (n = 8); n of serum samples: CTL (n = 4-6), GBS (n = 6-9), and GBS plus IL-1Ra (n = 6-8). CTL, control; ELISA, enzyme-linked immunosorbent assay; CXCL1, chemokine (C-X-C motif) ligand 1; G, gestational day; GBS, group B Streptococcus; IL-1Ra, IL-1 receptor antagonist; SEM, standard error of the mean.