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. 2022 Jul 1;13:833121. doi: 10.3389/fendo.2022.833121

Figure 2.

Figure 2

Administration of IL-1Ra to the dam decreased the levels of pro-inflammatory cytokines within GBS-infected placentas. Mean concentration of IL-1β (A), IL-6 (B), CXCL1 (C), and TNF-α (D) in placentas at 72 h quantified by ELISA. Data were collected from four individual experiments. Statistical analyses were done by one-way ANOVA or Kruskal-Wallis test with Dunnett’s or Dunn’s multiple comparisons multiple between the experimental groups (CTL, GBS, and GBS plus IL-1Ra); *p < 0.05. Bars show mean ± SEM. Number (n) of male and female placentas: CTL (male and female, n = 3-6), GBS (male and female, n = 4-7), and GBS plus IL-1Ra, (male and female, n = 6-7). CXCL1, chemokine (C-X-C motif) ligand 1; ELISA, enzyme-linked immunosorbent assay; F, female; GBS, group B Streptococcus; IL, interleukin; IL-1Ra, IL-1 receptor antagonist; M, male; SEM, standard error of the mean; Tx, treatment.