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. 2022 Jul 1;13:833121. doi: 10.3389/fendo.2022.833121

Figure 5.

Figure 5

Impact of IL-1Ra on fetal and placental weight in response to GBS infection. IL-1Ra positively controls the fetal and placental weight in response to GBS infection. Mean of placental weight (A), fetus weight (B) and the ratio of fetus placenta at G22 (C). Number (n) of placentas: CTL (male [n = 43), female (n = 23)], GBS [male (n = 38), female (n = 43)], and GBS plus IL-1Ra [male (n = 33), female (n = 32)]. Data were collected from four individual experiments. Analyses were done by ANOVA test separately for males and females with Dunnett’s multiple comparisons between groups (CTL, GBS, and GBS plus IL-1Ra) when treatment was significant. *p < 0.05, **p < 01, ****p ≤ 0.001 Bars show mean ± SEM. F, female; G, gestational day; GBS, group B Streptococcus; IL-1Ra, IL-1 receptor antagonist; M, male; SEM, standard error of the mean.