Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 14;140(2):140–151. doi: 10.1182/blood.2021014708

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by The American Society of Hematology.

Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

PMC Copyright notice

Figure 6. — Anti-FVIIa activity of plasma antithrombin (AT) in healthy control samples and carriers of mutations affecting the glycosylation at Asn224. (A) Formation of FVIIa-antithrombin complexes (FVIIa-AT) in vitro by incubation of plasma from carriers of both variants and a control subject, with recombinant FVIIa and UFH. FVIIa-AT complexes (C) and free antithrombin were detected by Western blotting. The image shows representative cases. Values from densitometry analysis of FVIIa-AT, free AT, and total AT are indicated. *arbitrary units. (B) Violin plots of FVIIa-AT complexes and ratio FVIIa-AT/total AT determined by densitometry in 3 carriers of the p.Asn224His and p.Glu227Lys variants and 4 healthy control samples after incubation with FVIIa and UFH. a.u., arbitrary units. *P < .05. (C) Violin plots of FVIIa-AT complexes determined by a specific ELISA in the same samples. The ratio FVIIa-AT/total AT is also shown. *P < .05.