FIGURE 10.

Molecular alterations in signaling pathways associated with neurodegeneration in fibroblasts derived from patients with FAD-PS1. The results of gene expression of brain samples from patients with ADF allowed for the identification of changes at the level of the autophagic-lysosomal pathway, as well as of kinases associated with hyperphosphorylation of the protein tau and its pathological phosphorylation. From the proteomic results, it was identified that fibroblasts with PS1 mutations present increased levels of cellular stress proteins, which could represent a compensation event through chaperone-mediated autophagy and also regulate the aggregation of the Aβ peptide and tau.