FIGURE 7.

Ontological subclassification of cellular processes of the proteins identified in fibroblasts derived from patients (AD1 and AD2) and controls (NA2 and NA3). From the ontological classification of molecular function, the subclassification of cellular processes (accounting for ∼30% of the proteins identified by mass spectrometry) was selected. (A) Distribution of proteins from fibroblasts of the control individuals according to the cellular process in which they are involved. (B) Distribution of proteins from fibroblasts of the FAD individuals according to the cellular process in which they are involved. In both panels, values are expressed as percentage of the number of the proteins identified in the molecular classification. The arrow and the box in red indicate the classification of protein folding. As shown in Supplementary Tables 2, 3, control individuals (NA2 and NA3) have lower numbers of protein folding-associated cellular stress response proteins.