. 2022 Jul 1;13:899923. doi: 10.3389/fgene.2022.899923

TABLE 1.

The primary results of the meta-analyses in exploring the relationship between gene polymorphisms and AR.

Gene	Polymorphisms	Minor allele	Total Studies	Number of patients		Model	heterogenity test	Fixed or random effects model	OR	CI	p.value	Funnel plot asymmetry linear regression test
Gene	Polymorphisms	Minor allele	Total Studies	AR	Control	allelic/genomic	p.value	Fixed or random effects model	OR	CI	p.value	t	p.value
TNFα	rs1800629−308G/A	A	5	1021	887	Allelic	0.004	Random	1.56	[1.00; 2.42]	0.05	−0.4	0.717
TGFβ1	rs1800469−509C/T	C	4	560	519	Allelic	<0.001	Random	0.89	[0.37; 2.12]	0.79	−0.51	0.659
IL-13	rs1800925−1112C>T	T	5	984	1284	Allelic	0.35	Fixed	0.99	[0.85; 1.17]	0.94	0.01	0.994
IL-13	rs20541+2044G>A	A	12	2924	2782	Allelic	0.05	Fixed	1.22	[1.12; 1.33]	<0.001	1.19	0.262
CTLA-4	rs3087243	A	3	1039	1142	Allelic	0.54	Fixed	1.06	[0.93; 1.20]	0.38	−3.7	0.168
	rs231725	G	3	1041	1134	Allelic	0.06	Random	0.81	[0.63; 1.05]	0.12	−4.81	0.13
	rs11571302	A	3	1040	1143	Allelic	0.17	Fixed	1.41	[1.24; 1.60]	<0.001	−10.67	0.059
	rs11571315	G	3	1041	1144	Allelic	0.14	Fixed	1.00	[0.89; 1.55]	0.97	4.29	0.146
IL-4	rs2243250−590C>T	T	8	1660	1807	Allelic	<0.001	Random	1.37	[0.95; 1.98]	1.37	0.71	0.506
	rs2227284T2979G	G	3	657	963	Allelic	<0.001	Random	1.56	[0.64; 3.80]	0.33	1.64	0.349
	rs2070874C−33T	C	3	597	962	Allelic	0.0003	Random	0.68	[0.34; 1.37]	0.28	−2.24	0.267
CD14	rs2569190−159C/T	T	10	1787	1820	Allelic	0.0007	Random	0.93	[0.78; 1.12]	0.46	1.71	0.126
FOXP3	rs3761548−3279A>C	A	5	935	925	Allelic	0.005	Random	0.89	[0.65; 1.20]	0.44	0.12	0.910
FOXP3	rs2232365−924A>C	C	4	796	763	Allelic	0.29	Fixed	0.97	[0.83; 1.13]	0.69	0.82	0.498
IL-18	rs1946518−607C/A	A	4	1362	833	Allelic	0.28	Fixed	1.02	[0.90; 1.16]	0.74	2.96	0.098
	rs187238−137G/C	C	3	1202	662	Allelic	0.73	Fixed	0.91	[0.78; 1.06]	0.22	2.22	0.269
	rs4988359/rs360721 C133/140G	G	3	1202	662	Allelic	0.41	Fixed	0.89	[0.77; 1.04]	0.14	10.68	0.059
Tim-3	rs10515746−574G/T	T	4	571	691	Allelic	0.14	Fixed	1.21	[0.78; 1.88]	0.40	2.84	0.105
IL-4R	rs1801275Q576R//Gln551Arg	R	9	924	920	Allelic	0.003	Random	1.48	[1.07; 2.05]	0.02	2.62	0.034*
IL-4R	rs1805010 I50V	V	3	179	197	Allelic	0.75	Fixed	0.84	[0.63; 1.13]	0.25	0.51	0.699
ACE	I/D	D	5	561	603	Allelic	0.03	Random	1.47	[1.09; 1.97]	0.01	1.25	0.301
TAP1	333V/I	V	4	231	270	Allelic	<0.001	Random	1.26	[0.50; 3.15]	0.62	−0.57	0.627
TAP1	637G/D	G	4	204	270	Allelic	<0.001	Random	0.72	[0.31; 1.69]	0.45	0.00	0.999