TABLE 1.

Plant derived compounds targeting the plasmids carrying AMR genes.

S. No.	Mechanisms	Plant name	Compound/Active extracts	Targets	References
1.	Plasmid conjugation inhibitors	Mallotus philippensis	Rottlerin, Red compound	Plasmids pKM101, pUB307, TP114 and R6K	Oyedemi et al., 2016; Patwardhan et al., 2018
2.		Penicillium citrinum isolated from a Porifera sp.	Tanzawaic acids A and B	IncW plasmid R388 and the IncFII plasmid R100-1	Getino et al., 2016
3.	Plasmid curing		Ascorbic acid		Amábile Cuevas, 1988
4.		Dioscorea bulbifera	8-epidiosbulbin E acetate	RP4, pUB110, RIP64, and R136	Shriram et al., 2008
5.		Alpinia galanga	1′-acetoxychavicol acetate	Plasmid RP4 and pUB110	Latha et al., 2009
6.		Piper longum	Aqueous and methanol extracts	Plasmid RP4pUB110	Chandra et al., 2017
7.		Terminalia chebula	Aqueous extract	pUB110 of and pARI-815	Vemuri et al., 2019
8.		Plumbago auriculata,	Root extracts	R- plasmids of bacterial strains	Singh et al., 2018
9.		Plumbago zeylanica	Plumbagin Lawsone	Conjugative plasmids pBR322, pUPI281, pRK2013, R136, and pUPI282	Patwardhan et al., 2018
10.		Capsicum annum	Capsaicin and dihydrocapsaicin, nonivamide, 6-gingerol and 6-shogaol	pUB307, pKM 101 and TP114	Oyedemi et al., 2019

The natural products derived from plants inhibit the plasmid conjugation, replication and segregation mechanisms, hence may play an important role in slowing down the dissemination of AMR genes.