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Consort diagram of patient inclusion in the study. (A) ER-positive cohort 1 and (B) ER-positive cohort 2. Patients with missing cores or insufficient tumor for analysis were excluded. Abbreviations: ER, estrogen receptor; TMA, tissue microarray; HIF-1α, hypoxia-inducible factor-1α; IHC, immunohistochemistry; CAIX, carbonic anhydrase IX.
