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. Author manuscript; available in PMC: 2022 Jul 15.
Published in final edited form as: Horm Metab Res. 2016 Nov 21;48(11):700–713. doi: 10.1055/s-0042-118458

Fig. 3.

Fig. 3

Modes of SSC-based tissue regeneration: cell replacement vs. trophic activity. SSCs migrate to the site of tissue injury and differentiate into functional cells to replace damaged cells. Besides their differentiation capacity, SSCs can enhance the intrinsic regenerative capacity of the tissues through the modulation of the immune system and the influence of released cytokines on the microenvironment. The concerted action of these factors and cells facilitates tissue repair through angiogenesis, remodeling of the extracellular matrix (ECM) and the differentiation of tissue progenitor cells [99].