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. Author manuscript; available in PMC: 2022 Jul 15.
Published in final edited form as: Nat Metab. 2021 Nov 18;3(11):1512–1520. doi: 10.1038/s42255-021-00465-w

Extended Data Fig. 4. Metabolomics of MTR knockout tumors.

Extended Data Fig. 4

(A) Water-soluble metabolites levels from individual HCT116 control and MTR knockout subcutaneous tumors (normalized to wild-type tumor average). (B) Relative abundance of an S-ribosylhomocysteine isomer in HCT116 control and MTR knockout subcutaneous tumors (mean ± SD, n = 10 tumors for control-1, and n = 9 tumors for each other group). (C) MS/MS spectrum of m/z 268.0848 peak in positive-ion mode. Fragmentation pattern suggests an S-ribosylhomocysteine (SRH) isomer. WT = wild-type.