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Time-activity curves of 111In-labeled CD137 in human CD137 knock-in mice bearing LLC/OVA/hGPC3 tumors on SPECT/CT images. Tracer uptakes were quantified at 5 min, 4 h, and days 1, 2, 3, and 4 after intravenous injection of 1.85 MBq of 111In-labeled Sta-MB, Ure-MB, Sta-mIgG1, and KLH-MB in the tumor (A), heart (B), and liver (C). Lines indicate each mouse and bold lines show the mean. The P values are shown (vs. Sta-MB). N.S., not significant.
