Table 2.
Biodistribution of 111In-labeled antibodies in human CD137 knock-in mice bearing LLC/OVA/hGPC3 tumors on day 4 after SPECT/CT.
| Tissue/Organ | Sta-MB | Ure-MB | Sta-mIgG1 | KLH-MB |
|---|---|---|---|---|
| Blood | 24.7 ± 3.5 | 1.8 ± 0.7** | 26.8 ± 3.8 | 20.5 ± 2.6 |
| Tumor | 26.8 ± 10.5 | 21.5 ± 4.7 | 24.5 ± 5.2 | 11.8 ± 1.5* |
| Lymph node | 7.4 ± 1.2 | 55.4 ± 10.2** | 13.4 ± 6.1 | 4.2 ± 1.6 |
| Heart | 5.5 ± 0.6 | 0.8 ± 0.1** | 5.8 ± 0.8 | 5.2 ± 0.6 |
| Lung | 9.0 ± 1.1 | 2.9 ± 0.3** | 9.3 ± 1.2 | 8.9 ± 2.2 |
| Liver | 22.9 ± 2.9 | 11.5 ± 1.6** | 11.4 ± 0.7** | 14.8 ± 0.9** |
| Spleen | 15.9 ± 1.9 | 88.7 ± 3.4** | 11.3 ± 1.9* | 14.8 ± 2.2 |
| Intestine | 2.9 ± 0.4 | 9.4 ± 2.0** | 3.0 ± 0.5 | 3.0 ± 0.4 |
| Kidney | 6.7 ± 0.8 | 2.1 ± 0.1** | 6.7 ± 1.0 | 6.7 ± 1.0 |
| Bone | 6.0 ± 0.7 | 5.2 ± 0.2 | 3.6 ± 0.5** | 5.2 ± 0.5 |
Data are expressed as the mean ± SD of %ID/g (n = 5). *P < 0.05, **P < 0.01, when compared with the Sta-MB group.