Table 5.
Significantly Enriched Pathways and Associated Differentially Regulated Genes in Corneal Stromal Cells of Patients With KC, Relative to Healthy Corneal Stromal Cells
| Name | Expected Number of Genes | Observed Number of Genes | Adjusted P | Upregulated Genes in Pathway | Downregulated Genes in Pathway |
|---|---|---|---|---|---|
| Metabolic pathways | 90.15 | 121 | 0.023 | ABO, ACSL3, ACSS1, ADI1, ALDH1A1, ALDH3A1, ALDH6A1, ALDH7A1, AMACR, ATP6V1G2, BCKDHB, CA14, CA6, CKMT2, COX4I2, COX6B2, CYP17A1, CYP26A1, CYP2B6, DBT, EPHX2, EXTL2, FECH, GART, GLS, GLUL, GSTT2, GSTT2B, HIBCH, HSD17B8, HYAL4, ITPKB, KMO, LRTOMT, MOCS1, NAPRT, NMNAT1, OGDHL, PANK1, PCK1, PIGV, PLCB4, PLCD1, PLCD4, PMVK, SC5D, SELENBP1, SQOR, ST6GAL1, ST6GALNAC5, TBXAS1, TK2 | ACSL4, ACSL5, ADA, ADCY3, ADPGK, AK2, AKR1B1, ALOX5, AMPD2, ARG2, BDH1, CA13, CANT1, CERS4, CHDH, CHST8, CMPK2, DEGS1, DGKD, DHRS9, ENPP4, ETNK1, EXT1, FPGS, FUT2, FUT3, FUT6, GALNT1, GALNT14, GALNT5, GCNT3, GNE, GYS1, HK2, HPRT1, IDH2, IDO1, IDS, INPP5E, ITPKA, LAP3, MGAT4B, MGST1, MRI1, MTHFD1L, MTHFR, NAMPT, NDUFA4L2, NT5C3B, NT5E, PDE4A, PDE7B, PDE9A, PFKFB3, PGS1, PIGL, PLB1, PRPS1L1, PRPS2, PTGS1, PTGS2, QPRT, RIMKLA, SGSH, SPTLC1, SYNJ2, TYMS, UGT1A6, UGT1A8 |
| MAPK signaling pathway | 18.7 | 37 | 0.021 | CACNA1H, CACNA2D3, FGF9, FGFR2, FGFR4, HSPA1A, HSPA1B, MAP2K6, MAP3K20, MAP4K2, MAPK10, NF1, NLK, NTRK2, RASGRF1, RPS6KA5 | AKT2, ARAF, AREG, CDC25B, DUSP4, DUSP8, GNA12, IL1B, IL1R1, IL1RAP, MAP3K14, MAP3K8, MAPK9, MAPT, MAX, PAK1, PGF, PPP3CC, RAC2, RELB, VEGFA |
| Focal adhesion | 12.5 | 28 | 0.010 | COL4A4, COMP, LAMA4, MAPK10, RASGRF1, THBS4 | ACTN1, AKT2, CCND2, COL4A2, COL9A3, ITGA5, ITGB6, LAMA1, LAMC3, MAPK9, MYLK, PAK1, PGF, PPP1R12B, PXN, RAC2, SHC1, SPP1, THBS1, VAV1, VEGFA, ZYX |
| TNF signaling pathway | 7.14 | 18 | 0.021 | AKT2, BCL3, CXCL1, CXCL2, CXCL5, IL15, IL1B, IRF1, MAP3K14, MAP3K8, MAPK9, MMP9, PTGS2, SOCS3 | CFLAR, MAP2K6, MAPK10, RPS6KA5 |
| IL-17 pathway | 6.16 | 15 | 0.037 | MAPK10 | CXCL1, CXCL2, CXCL5, DEFB4A, IL17RA, IL1B, LCN2, MAPK9, MMP9, PTGS2, S100A8, S100A9, TRAF3IP2, USP25 |
| Prolactin signaling pathway | 4.52 | 13 | 0.025 | CYP17A1, ESR1, MAPK10 | AKT2, CCND2, IRF1, JAK2, MAPK9, SHC1, SOCS1, SOCS2, SOCS3, STAT1 |