Table 1.
Property of cells | Control 48 h (n = 5) |
Running 48 h (n = 5) |
Control 4 weeks (n = 5) |
Running 4 weeks (n = 8) |
---|---|---|---|---|
GFP+ cells | 265 (66) | 260 (45) | 87 (22) | 130 (38) |
Spread (mm) | 1.54 (0.16) | 1.58 (0.16) | 1.82 (0.28) | 1.47 (0.21) |
NeuN (%) | 0 | 0 | 2.2 (1.3) | 27.4 (9.3)** |
Calbindin (%) | 0 | 0 | 2.0 (1.2) | 22.5 (9.3)** |
Tuj1-β (%) | 9.2 (1.1) | 28.4 (8.3)* | 15.6 (6.9) | 31.7 (3.6)* |
NG2 (%) | 26.0 (12.2) | 35.0 (2.3)* | 7.7 (5.0) | 13.7 (3.8) |
GFAP (%) | 4.1 (1.9) | 4.6 (3.6) | 10.3 (4.2) | 8.6 (1.5) |
The total number of GFP+ cells from the dentate gyrus is shown at indicated time points after viral injection. At 48 h, runners had a greater percentage of GFP+ cells labelled for Tuj1-β (P < 0.04) and NG2 (P < 0.05) than controls. At 4 weeks, the percentage of GFP+ cells co-labelling with neuronal markers was significantly higher in runners than in controls (NeuN, P < 0.01; calbindin, P < 0.01; Tuj1-β, P < 0.04). All data are presented as means, with s.e.m. in parentheses. Asterisk, P < 0.05; double asterisk, P < 0.01.