Table 2.
Morphological characteristic | Four-week-old neurons | Four-month-old neurons | Statistical significance (P) |
---|---|---|---|
Area of soma* (µm2) | 80.0 (5.6) | 138 (14) | 0.002 |
Total dendritic length (µm) | 359 (45) | 552 (49) | 0.01 |
Number of branch points | 4.1 (0.7) | 6.8 (0.6) | 0.01 |
Spine density† (µm−1) | 0.77 (0.04) | 1.19 (0.07) | 0.0002 |
Data are presented as means, with s.e.m. in parentheses. The column on the right shows the statistical signifcance, calculated using a t-test. n = 8 for all characteristics, except spine density for 4-month-old neurons, where n = 5.
Maximal cross-sectional area obtained from stereological measurements.
Measured over a total dendritic length of 607 µm in newly generated cells at 4 weeks and 638 µm at 4 months after virus injection. The distances between the cell body and the beginning of the measured dendritic segments were similar for the 4-week-old (71 ± 9 µm) and 4-month-old (57 ± 5 µm) neurons (P = 0:2).