Table 2.
H1 sub-haplotypes associated with PD susceptibility
| Stage 1 | Stage 2 | Meta | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Block | Sub-haplotype ID | Sub-haplotype | Frequency (Case/Control) |
OR (95% CI) |
OR Fisher's exact psig | Frequency (Case/Control) |
OR (95% CI) |
OR Fisher's exact psig | RE OR (95% CI) | RE Heterogeneity (p) | RE psig | FE OR (95% CI) | FE Heterogeneity (p) | FE psig |
| H1.1 | H1.1a | ACTCT | 0.25 (0.26/0.24) | 1 | - | 0.21 (0.2/0.23) | 1 | - | 1 | - | - | 1 | - | - |
| H1.1b | ACTTG | 0.27 (0.38/0.22) |
1.6 (1.45–1.78) |
2.04E-19*** | 0.38 (0.39/0.36) |
1.26 (1.09–1.46) |
2.0E-03** |
1.43 (1.13–1.81) |
7.06 (0.0079) |
3.0E-03** |
1.48 (1.36–1.61) |
7.06 (0.0079) |
0*** | |
| H1.1c | GCCTG | 0.18 (0.09/0.23) |
0.37 (0.32–0.42) |
1.3E-49*** | 0.14 (0.13/0.16) |
0.96 (0.79–1.15) |
6.40E-01 |
0.59 (0.23–1.52) |
67.79 (< 0.0001) |
2.70E-01 |
0.51 (0.46–0.57) |
67.85 (< 0.0001) | 0*** | |
| H1.1d | ATCTG | 0.18 (0.06/0.24) |
0.22 (0.19–0.26) |
6.5E-92*** | 0.23 (0.24/0.21) |
1.29 (1.1–1.52) |
2.0E-03** |
0.54 (0.1–3.01) |
231.51 (< 0.0001) |
4.90E-01 |
0.49 (0.44–0.55) |
232.74 (< 0.0001) | 0*** | |
| H1.1e | ACCTG | 0.12 (0.21/0.08) |
2.51 (2.2–2.86) |
2.4E-45*** | 0.02 (0.02/0.02) |
1.45 (0.98–2.17) |
5.70E-02 |
1.97 (1.15–3.36) |
7.13 (0.0079) |
1.3E-02* |
2.37 (2.1–2.68) |
7.13 (0.0076) |
0*** | |
| H1.2 | H1.2a | TTTCGATG | 0.48 (0.44/0.5) | 1 | - | 0.49 (0.49/0.48) | 1 | - | 1 | - | - | 1 | - | - |
| H1.2b | TCTCGATG | 0.17 (0.18/0.16) |
1.27 (1.14–1.4) |
2.02E-05*** | 0.17 (0.17/0.18) |
0.93 (0.8–1.09) |
3.56E-01 |
1.09 (0.81–1.47) |
10.57 (0.001) |
5.70E-01 |
1.14 (1.04–1.24) |
10.58 (0.0011) |
3.0E-03** | |
| H1.2c | TTAAAATA | 0.15 (0.16/0.14) |
1.31 (1.16–1.47) |
4.52E-06*** | 0.19 (0.21/0.18) |
1.12 (0.97–1.3) |
1.21E-01 |
1.22 (1.05–1.42) |
2.65 (0.103) |
9.0E-03** |
1.23 (1.13–1.35) |
2.65 (0.1037) |
4.41E-06*** | |
| H1.2d | TTAAGATG | 0.07 (0.08/0.06) |
1.36 (1.16–1.59) |
1.2E-04*** | 0.04 (0.03/0.05) |
0.52 (0.38–0.69) |
3.46E-06*** |
0.84 (0.33–2.19) |
35.25 (< 0.0001) |
7.27E-01 |
1.07 (0.94–1.23) |
35.28 (< 0.0001) | 2.90E-01 | |
| H1.2e | CTTCGATG | 0.06 (0.06/0.06) |
1.17 (0.99–1.39) |
5.64E-02 | 0.08 (0.08/0.08) |
1.05 (0.85–1.3) |
6.76E-01 |
1.12 (0.99–1.28) |
0.72 (0.40) |
7.00E-02 |
1.12 (0.99–1.28) |
0.72 (0.397) |
7.00E-02 | |
| H1.2f | TTTCGGTG | 0.05 (0.05/0.05) |
1.16 (0.96–1.39) |
1.18E-01 | 0.02 (0.02/0.03) |
0.58 (0.41–0.83) |
7.1E-03** |
0.83 (0.42–1.64) |
12.41 (0.0004) |
6.00E-01 |
0.99 (0.84–1.16) |
12.41 (0.0004) |
9.10E-01 | |
| H1.2 g | TTAAAATG | 0.01 (0.01/0.01) |
1.1 (0.77–1.54) |
6.07E-01 | - | - | - | - | - | - | - | - | - | |
| H1.2 h | TTTCGACG | 0.01 (0.01/0.01) |
1.28 (0.89–1.84) |
1.64E-01 | - | - | - | - | - | - | - | - | - | |
| H1.3 | H1.3a | GACTGAGAT | 0.28 (0.32/0.27) | 1 | - | 0.32 (0.32/0.32) | 1 | - | 1 | - | - | 1 | - | - |
| H1.3b | CATTAGGGC | 0.18 (0.11/0.22) |
0.43 (0.38–0.49) |
1.66E-41*** | 0.18 (0.18/0.19) |
0.95 (0.81–1.11) |
5.22E-01 |
0.64 (0.29–1.44) |
58.53 (< 0.0001) |
2.80E-01 |
0.57 (0.52–0.63) |
58.57 (< 0.0001) | 0*** | |
| H1.3c | GATTGAGAT | 0.17 (0.21/0.16) |
1.11 (0.99–1.24) |
7.37E-02 | 0.16 (0.16/0.17) |
0.95 (0.80–1.12) |
5.33E-01 |
1.04 (0.89–1.21) |
2.24 (0.134) |
6.10E-01 |
1.06 (0.96–1.16) |
2.24 (0.1343) |
0.23 | |
| H1.3d | CTTTGGTGC | 0.15 (0.12/0.16) |
0.61 (0.54–0.7) |
1.58E-14*** | 0.2 (0.21/0.18) |
1.16 (0.99–1.36) |
5.81E-02 |
0.84 (0.45–1.56) |
35.27 (< 0.0001) |
5.80E-01 |
0.77 (0.7–0.85) |
35.28 (< 0.0001) | 2.96E-07*** | |
| H1.3e | CATTGGGGC | 0.09 (0.14/0.07) |
1.67 (1.45–1.92) |
2.79E-13*** | 0.02 (0.02/0.02) |
0.81 (0.54–1.21) |
2.83E-01 |
1.19 (0.58–2.42) |
12.01 (0.0004) |
6.30E-01 |
1.54 (1.35–1.75) |
12.01 (0.0005) |
4.57E-11*** | |
| H1.3f | CATTGGGGT | 0.08 (0.07/0.09) |
0.6 (0.51–0.70) |
9.34E-11*** | 0.09 (0.1/0.08) |
1.15 (0.93–1.42) |
2.00E-01 |
0.81 (0.44–1.5) |
21.37 (< 0.0001) |
5.10E-01 |
0.74 (0.66–0.84) |
21.38 (< 0.0001) | 3.59E-06*** | |
| H1.3 g | GATCGAGAT | 0.04 (0.04/0.04) |
0.83 (0.67–1.03) |
9.39E-02 | 0.03 (0.02/0.02) |
0.55 (0.38–0.78) |
5.58E-04*** |
0.7 (0.49–1.02) |
3.48 (0.062) |
6.60E-02 |
0.75 (0.63–0.9) |
3.48 (0.062) | 1.6E-03** | |
OR Odds ratio, CI Confidence interval, RE Random effects meta-analysis, FE Fixed effects meta-analysis. *p < 0.05, **p < 0.01, ***p < 0.001