Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 15;21:146. doi: 10.1186/s12943-022-01607-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 7 — UBE3C was a ubiquitin E3 ligase which mediated the ubiquitination of PEBP1. a Co-IP with PEBP1 antibody confirmed the existence of UBE3C in the precipitates of PEBP1. b Immunofluorescence analysis of the localization of PEBP1 (red) and UBE3C (green). c RNA pull-down confirmed the binding of circPOLR2A and UBE3C. d RIP assay indicated the association between circPOLR2A and UBE3C. e RNA FISH and immunofluorescence analysis of the localization of UBE3C (red) and circPOLR2A (green). f The protein expression of PEBP1 after UBE3C knockdown in cRCC cells. Left, 786O cells; right, Caki1 cells. g, h PEBP1 ubiquitination was detected after UBE3C knockdown. 7 g, 786O cells; 7 h, Caki1 cells