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. 2022 Jul 15;21:146. doi: 10.1186/s12943-022-01607-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — CircPOLR2A inhibited the growth and metastasis of cRCC cells in vivo. a Tumor size and weight of the subcutaneous tumor growth model injected with cRCC cells (5 mice/group); b IHC staining of the indicated proteins in the tumor samples obtained from the subcutaneous tumor growth model. Top, Ki-67; middle, cleaved caspase 3; bottom, PEBP1. c Representative bioluminescent images of lungs for each experimental group after 6 weeks (5 mice/group). d Representative images of lung and HE staining of lung metastases. e Statistical analysis of the number of metastatic nodules in lung