Fig. 5.

Wnt/β‐catenin was downstream regulated by METTL3 and miR-221/222. A Venn diagram indicating the targets of miR-221/222 in human, rat, and mouse. B KEGG analysis of the 289 intersection target genes of three species. C GO analysis of the 289 intersection target genes of three species. D Western blot detected the expression of β‐catenin and c-Myc in NRCMs stimulated with Ang-II. n = 3. E qRT-PCR detected the expression of c-Myc in NRCMs stimulated with Ang-II. n = 3. F Western blot detected the expression of β‐catenin and c-Myc in Ang-II-induced NRCMs with METTL3 knockdown. n = 3. G qRT-PCR detected the expression of c-Myc in Ang-II-induced NRCMs with METTL3 knockdown. n = 3. H Western blot detected the expression of β‐catenin and c-Myc in Ang-II-induced NRCMs with miR-221/222 inhibition. n = 3. I qRT-PCR detected the expression of c-Myc in Ang-II-induced NRCMs with miR-221/222 inhibition. n = 3. *P < 0.05, **P < 0.01, ***P < 0.001