Table 2.

Detailed early PET/CT metrics and association with EOT response

Early PET/CT result		EOT responder (n=9)†	EOT non-responder (n=7)†	P – value
D4 Visual	24
Response (CR + PR)	14 (58)	4 (50)	4 (57)	1.0
Non-response (SD + PD)	10 (42)	4 (50)	3 (43)
D4 ΔSUVmax	23
>50%	10 (43)	5 (71)	2 (29)	0.29
≤50%	13 (57)	2 (29)	5 (71)
D4 ΔSUVmax, median (range)	45 (−76 – 89)*	57	37	0.37
D21 Visual	22
Response (CR + PR)	7 (32)	3 (38)	2 (33)	1.0
Non-response (SD + PD)	15 (68)	5 (62)	4 (67)
D21 ΔSUVmax	21
>50%	5 (24)	3 (43)	1 (17)	0.56
≤50%	16 (76)	4 (57)	5 (83)
D21 ΔSUVmax, median (range)	26 (−140 – 89)*	42	29	0.94
Response on D4 & D21	23
Y	6 (26)	3 (38)	1 (17)	0.58
N	17 (74)	5 (62)	5 (83)
ΔSUVmax >50% on D4 & D21	22
Y	4 (18)	3 (43)	0 (0)	0.19
N	18 (82)	4 (57)	6 (100)

^*positive number represents decrease in SUVmax

^†Excludes patients who did have early PET/CTs performed but were missing EOT PET/CT evaluation

PET/CT, positron emission tomography/computed tomography; EOT, end-of-treatment; D4, day 4; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; SUVmax, maximum standardized uptake value; D21, day 21