Table 1.

A summary of the published cryo-EM structures of TRPV1 and TRPM8 channels.

Channel	Ligand	Biochemical condition	Structure annotation	Resolution	PDB ID	Reference
TRPV1	Apo	Amphipol	TRPV1-Apo	3.4 Å	3J5P	[41]
	DkTx/RTx	Amphipol	TRPV1-DkTx/RTx	3.8 Å	3J5Q	[40]
	Capsaicin	Amphipol	TRPV1-Capsaicin	4.2 Å	3J5R
	Apo	Lipid nanodiscs	TRPV1ND-Apo	3.28 Å	5IRZ	[42]
	DkTx/RTx	Lipid nanodiscs	TRPV1ND-DkTx/RTx	2.95 Å	5IRX
	Capsazepine	Lipid nanodiscs	TRPV1ND-Capsazepine	3.43 Å	5IS0
TRPM8FA	Apo	Detergent	TRPM8FA-Apo	4.1 Å	6BPQ	[43]
	PI(4,5)P2/icilin/Ca2+	Detergent	TRPM8FA-PI(4,5)P2/icilin/Ca2+ class 1	3.4 Å	6NR3	[44]
			TRPM8FA-PI(4,5)P2/icilin/Ca2+ class 2	4.3 Å	6NR4
	PI(4,5)P2/WS-12	Detergent	TRPM8FA-PI(4,5)P2/WS-12	4.0 Å	6NR2
TRPM8PM	Apo	Amphipol	TRPM8PM-Apo	3.6 Å	6O6A	[45]
	AMTB	Amphipol	TRPM8PM-AMTB	3.2 Å	6O6R
	TC-I 2014	Amphipol	TRPM8PM-TC-I 2014	3 Å	6O72
	Ca2+	Amphipol	TRPM8PM-Ca2+	3.2 Å	6O77