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. 2022 Jul 15;12:12118. doi: 10.1038/s41598-022-16328-7

Table 1.

The characteristics of 104 studies.

Study Country Survey time Sampling method Sample size (n =) Age (year) Gender (male/female) Educational level Majors Psychological stress Assessment tool Investigation method
Gong Chen 2020 China 2020.5.2 ~ 2020.5.9 Handy sampling 4750  ≥ 18 1652/3098

Undergraduate (4184)

Postgraduate (566)

Medical Anxiety SAS Questionnaire
Minjiang Ding 2020 China 2020.1 Random sampling 3055  ≥ 18 1420/1635

Undergraduate (2993)

Postgraduate (62)

Multiversity Fear, Anxiety Self-made scale Questionnaire
Lan Gao 2020 China 2020.2.11 ~ 2020.2.16 Handy sampling 5593 21 ± 2 2290/3303 Undergraduate Medical Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Gaowen Yu 2020 China NR Random sampling 427 NR 98/329 Undergraduate Multiversity Depression, Anxiety SAS, SDS Questionnaire
Qingxiang Yu 2020 China 2020.2.9 ~ 2020.2.10 Random sampling 2074 NR 1087/987

Junior (747)

Senior (1327)

/ Depression, Anxiety, fear Self-made scale Questionnaire
Benyu Zhang 2020 China 2020.2.6 ~ 2020.5.26 Cluster sampling 5151  ≥ 18 1374/3777 Undergraduate Multiversity Anxiety, Fear RQ-20, SAS Questionnaire
Xiaolu Zhang 2020 China 2020.2 Random sampling 1486 21.69 ± 2.27 453/1033

Undergraduate (1371)

Postgraduate (115)

Medical Depression, Anxiety, Fear PHQ-9, GAD-7, SSRS Questionnaire
Xuehui Zhang 2020 China 2020.2.1 ~ 2020.2.8 Handy sampling 1209 21.89 ± 3.43 527/682

Undergraduate (755)

Postgraduate (454)

Medical Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Chunz Zhao 2020 China NR Handy sampling 376  ≥ 18 73/303 Undergraduate Multiversity Depression, Anxiety, Fear Self-made scale Questionnaire
Kaiheng Zhu 2020 China 2020.2.28 ~ 2020.3.5 Random sampling 1264 NR 707/557 Primary / Anxiety SCARED Questionnaire
Xiaolin Zhu 2020 China 2020.1.30 ~ 2020.2.13 Handy sampling 1482 21 ± 3 458/1024

Senior (171)

Undergraduate (1027)

Postgraduate (284)

Multiversity Depression, Anxiety, Pressure SRQ-20, PHQ-9, GAD-7 Questionnaire
Zengli Zou 2020 China 2020.2.15 ~ 2020.2.29 Handy sampling 25,286  ≥ 18 7548/17,738

Undergraduate (24,157)

Postgraduate (1129)

Medical Anxiety SAS Questionnaire
Erke Ke 2021 China 2020.3 ~ 2020.4 Handy sampling 7755 10.73 ± 2.98 4249/3506

Primary (5282)

Junior (1728)

Senior (745)

/ Anxiety PSQ Questionnaire
Limu Ke 2021 China 2020.2.4. ~ 2020.4.26 Handy sampling 1110 21.08 ± 1.85 395/715 Undergraduate Medical Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Pei Deng 2021 China 2020.2 Handy sampling 517  ≥ 18 135/382 Undergraduate Multiversity Anxiety SAS Questionnaire
Jinghui Chang 2020 China 2019.1.13 ~ 2020.2.3 Handy sampling 3881 19 ~ 20 1434/2447 Undergraduate Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Shushen Zheng 2020 China NR Handy sampling 3823 20.03 ± 1.43 1293/2530 Undergraduate Medical Depression, Anxiety SAS, SDS, SSRS Questionnaire
Wen Zhang 2021 China 2020.4 ~ 2020.5 Stratified sampling 7719  ≥ 18 2686/5033 Undergraduate Multiversity Anxiety, Fear Self-made scale Questionnaire
Xi Liu 2021 China NR Handy sampling 1841 20.42 ± 1.70 773/1068 Undergraduate Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Ya Wang 2020 China 2020.2 Handy sampling 3178  ≥ 18 878/2300

Undergraduate (3170)

Postgraduate (8)

Multiversity Depression, Anxiety HAMA, SDS Questionnaire
Pengfei Bi 2021 China NR Random sampling 330 18 ~ 23 68/262 Undergraduate Medical Depression, Anxiety, Pressure DASS-21 Questionnaire
Xiaopan Shi 2021 China 2020.2.25 ~ 2020.3.8 Handy sampling 1830 NR 561/1269 Undergraduate Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Xingjie Yang 2020 China 2020.3.8 ~ 2020.3.15 Handy sampling 4139  ≥ 18 1431/2708 Undergraduate Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Dandan Shi 2022 China 2020.9 Handy sampling 7838  ≥ 18 3011/4827 Undergraduate Medical Depression, Anxiety, Fear, Pressure SCL-90 Questionnaire
Daokai Sun 2021 China NR Handy sampling 1297  ≥ 18 597/700 Undergraduate Multiversity Anxiety GAD-7 Questionnaire
Hongli Sun 2021 China 2020.2.6 ~ 2020.3.5 Random sampling 2597 NR 830/1767 Undergraduate Multiversity Fear Self-made scale Questionnaire
Yuelong Jin 2021 China 2020.6 ~ 2020.7 Cluster sampling 3781 20.37 ± 1.31 1950/1831 Undergraduate Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Yan Jiang 2020 China 2020.2.27 ~ 2020.2.29 Handy sampling 339 NR 162/237 Undergraduate Medical Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Zhujun Jin 2021 China 2020.3 Handy sampling 569 NR 176/393 Undergraduate Multiversity Depression, Anxiety, Fear, Pressure Self-made scale Questionnaire
Yanping Li 2021 China 2020.5 Handy sampling 449 18 ~ 26 218/231 Undergraduate Multiversity Anxiety SAS Questionnaire
Hao Wang 2022 China 2020.2.23 ~ 2020.4.5 Handy sampling 3641 22.5 ± 2.35 1029/2612 Undergraduate Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Renli Li 2020 China 2019.9 ~ 2020.4 Random sampling 2603  ≥ 18 1226/1377 Undergraduate Multiversity Depression, Anxiety, fear SCL-90 Questionnaire
Yue Li 2021 China 2020.2 Stratified sampling 2640 NR 824/1816 Undergraduate Multiversity Anxiety SAS Questionnaire
Peijun Liu 2021 China 2020.3.8 ~ 2020.3.14 Handy sampling 721 20.27 ± 2.87 238/483

Undergraduate (585)

Postgraduate (136)

Medical Anxiety SAS Questionnaire
Shuai Wang 2020 China 2020.3.8 ~ 2020.3.12 Handy sampling 1365 18 ~ 28 540/825

Undergraduate (1047)

Postgraduate (318)

Multiversity Anxiety SAS Questionnaire
Shaoyong Ma 2021 China 2020.2.2 ~ 2020.2.6 Handy sampling 6276 20.31 ± 1.51 1736/4540 Undergraduate Medical Anxiety SAS Questionnaire
Qianwen Qiu 2020 China 2020.2.16 ~ 2020.2.20 Handy sampling 1100 18 ~ 25 315/785 Undergraduate Multiversity Anxiety SAS Questionnaire
Jing Wang 2021 China 2020.2.18 ~ 2020.2.20 Handy sampling 840 20.16 ± 2.16 276/564

Undergraduate (795)

Postgraduate (48)

Multiversity Depression, Anxiety SAS, SDS Questionnaire
Nan Wu 2021 China 2020.6.9 ~ 2020.6.12 Cluster sampling 2702 20.5 ± 0.9 672/2025 Undergraduate Medical Depression, Anxiety SAS, SDS Questionnaire
Shuyin Wu 2021 China 2020.3 Handy sampling 941 21.8 ± 2.5 381/560

Undergraduate (811)

Postgraduate (130)

Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Ruichen Jiang 2020 China 2020.2 Cluster sampling 472 NR 196/276 Undergraduate Multiversity Depression, Anxiety, Pressure SCL-90 Questionnaire
Huiqi Wang 2020 China 2020.2.16 ~ 2020.2.18 Handy sampling 661 17.34 ± 1.60 305/356 Senior / Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Yuany Yang 2020 China 2020.2.7 ~ 2020.2.9 Handy sampling 1667 20.57 ± 2.00 803/864

Undergraduate (1546)

Postgraduate (121)

Multiversity Depression, Anxiety, fear PQEEPH Questionnaire
Yuanyuan Zhu 2021 China 2020.3.6 ~ 2020.4.1 Handy sampling 342 20.72 ± 1.39 45/297 Undergraduate Medical Depression, Anxiety PHQ-9, GAD-7, ERQ Questionnaire
Lina Zhao 2021 China 2020.3.20 ~ 2020.4.10 Handy sampling 666  ≥ 20 262/404 Undergraduate Medical Depression PHQ-9 Questionnaire
Bo Zhao 2021 China, Korea 2020.3.23 ~ 2020.4.12 Handy sampling 420 22.90 ± 3.30 133/287 Undergraduate Multiversity Depression PHQ-9 Questionnaire
Yiman Huang 2021 China 2020.2 ~ 2020.3 Handy sampling 3133 20.83 ± 1.53 889/2224 Undergraduate Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Chengqi Cao 2021 China 2020.7.13 ~ 2020.7.29 Handy sampling 57,984 14.8 ± 1.6 28,089/29,895

Junior (41,158)

Senior (16,826)

/ Depression, Anxiety, Pressure PHQ-9, GAD-7, GPS-T Questionnaire
Xudong Zhang 2021 China 2020.2.21 ~ 2020.2.24 Handy sampling 2270 18 ~ 25 877/1393 Undergraduate Multiversity Depression, Anxiety, Pressure SAS, SDS, YBOCS Questionnaire
Yanqiu Yu 2021 China 2020.2.1 ~ 2020.2.10 Handy sampling 23,863 NR 7605/16,258 Undergraduate (23,326) Postgraduate (537) Multiversity Depression, Anxiety, Fear PHQ-9 Questionnaire
Mingli Yu 2021 China 2020.3.3 ~ 2020.3.15 Handy sampling 1681  ≥ 18 592/1089 Undergraduate Multiversity Depression CES-D Questionnaire
Xinli Chi 2020 China 2020.5.13 ~ 2020.5.20 Handy sampling 1794 15.26 ± 0.47 1007/787 Junior / Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Z.Ma 2020 China 2020.2.3 ~ 2020.2.10 Handy sampling 746,217 18 ~ 26 331,613/414,604 Undergraduate Multiversity Depression, Anxiety, Pressure IES-6, PHQ-9, GAD-7 Questionnaire
Wenning Fu 2021 China 2020.5.10 ~ 2020.6.10 Handy sampling 89,588 18 ~ 30 39,194/50,394 Undergraduate Multiversity Anxiety GAD-7 Questionnaire
Jincong Yu 2021 China 2020.7 ~ 2020.8 Handy sampling 9383 NR 2685/6698 Undergraduate Multiversity Depression PHQ-9 Questionnaire
Juan Wang 2021 China 2020.2.4 ~ 2020.2.11 Handy sampling 538,500 6 ~ 12 287,189/251,311 Primary / Anxiety GAD-7 Questionnaire
Qingqing Xu 2021 China 2020.2.4 ~ 2020.2.12 Cluster sampling 373,216 15.24 ± 1.59 193,507/179,709

Junior (244,193)

Senior (129,023)

/ Anxiety GAD-7 Questionnaire
Xiaobin Zhang 2021 China 2021.1 ~ 2021.2 Handy sampling 22,380 12 ~ 17 11,809/10,571 Junior / Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Yi Zhang 2021 China 2020.2.4 ~ 2020.2.12 Handy sampling 11,787 20.51 ± 1.88 5056/6731 Undergraduate Multiversity Depression PHQ-9 Questionnaire
Weiwei Chang 2021 China 2019.12 ~ 2020.6 Handy sampling 4115 20.27 ± 1.30 1626/2489 Undergraduate Medical Depression, Anxiety, Pressure DASS-21 Questionnaire
Mingqiang Xiang 2020 China 2020.2.25 ~ 2020.3.5 Handy sampling 1396 20.68 ± 1.84 881/515 Undergraduate (1314) Postgraduate (82) Multiversity Depression, Anxiety SAS, SDS Questionnaire
Jingyi Wang 2021 China 2020.4.16 ~ 2020.5.14 Handy sampling 6435 15.6 ± 1.7 3204/3231 Senior / Depression CDI Questionnaire
Chenyang Lin 2022 China 2020.6.12 ~ 2020.7.14 Handy sampling 1881 21.39 ± 2.48 976/905

Undergraduate (1302)

Postgraduate (579)

Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Pei Xiao 2021 China 2020.10 ~ 2020.12 Cluster sampling 3951 19.58 ± 1.67 1674/2277 Undergraduate Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Xiaolei Zheng 2021 China 2020.12.17 ~ 2020.12.19 Random sampling 954 21.1 ± 1.2 366/588

Undergraduate (877)

Postgraduate (77)

Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Kaihan Yang 2021 China 2020.4 ~ 2020.5 Handy sampling 521 22.02 ± 1.76 117/404

Undergraduate (481)

Postgraduate (40)

Multiversity Anxiety, Fear, Pressure SAS, SRQ-20 Questionnaire
Peng Xiong 2021 China 2020.2.20 ~ 2020.3.20 Handy sampling 563 21.52 ± 2.50 172/391

Undergraduate (456)

Postgraduate(107)

Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Xiaoyan Wu 2021 China 2020.2.4 ~ 2020.2.12 Random sampling 11,787 20.45 ± 1.76 5056/6731 Undergraduate Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Luke 2021 Malaysia 2020.7.1 ~ 2020.7.21 Handy sampling 316 18 ~ 31 95/221 Undergraduate Medical Depression, Anxiety, Pressure DASS-21 Questionnaire
Dongfang Wang 2021 China 2020.6.1 ~ 2020.6.15 Handy sampling 8921 21.59 ± 1.81 3064/5857

Undergraduate (7428)

Postgraduate (1493)

Multiversity Depression, Anxiety, Pressure PHQ-9, GAD-7, IES-6 Questionnaire
Villani 2021 Italy 2020.6.8 ~ 2020.7.12 Handy sampling 501 21 ~ 24 143/358 Undergraduate Multiversity Depression, Anxiety, Fear SAS, SDS, PHE-2 Questionnaire
Simegn2021 Ethiopia 2020.6.30 ~ 2020.7.30 Handy sampling 423 18 ~ 34 272/151 Undergraduate Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Xiaomei Wang 2020 America 2020.5.4 ~ 2020.5.19 Handy sampling 2031 22.88 ± 5.52 779/1252

Undergraduate (1405)

Postgraduate (626)

Multiversity Depression, Anxiety, Pressure PHQ-9, GAD-7 Questionnaire
Sundarasen 2020 Malaysia 2020.4.20 ~ 2020.5.24 Handy sampling 983 17 ~ 25 330/653

Undergraduate (876)

Postgraduate (107)

Multiversity Anxiety SAS Questionnaire
Chinna 2021 Asia 2020.4 ~ 2020.5 Handy sampling 3679 NR 1519/2160 Undergraduate Multiversity Anxiety SAS Questionnaire
Karen 2021 Australia 2020.8 ~ 2020.9 Handy sampling 638  ≥ 18 NR Undergraduate Medical Depression, Anxiety, Pressure DASS-21 Questionnaire
Radwan 2021 Palestine 2020.6.10 ~ 2020.7.13 Random sampling 420 10 ~ 18 137/283 Senior / Depression, Anxiety, Pressure DASS-21 Questionnaire
Alsolais 2021 Saudi Arabia 2020.4.22 ~ 2020.5.16 Handy sampling 492 21.77 ± 2.47 218/274 Undergraduate Medical Depression, Anxiety, Pressure, Fear DASS-21 Questionnaire
Abay 2021 Ethiopia 2020.4.15 ~ 2020.515 Handy sampling 408  ≥ 18 214/194 Undergraduate Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Ririn 2021 India 2020.4 ~ 2020.5 Stratified sampling 247 17 ~ 24 23/224 Undergraduate Medical Anxiety SAS Questionnaire
Emilijus 2021 Lithuania 2021.1.31 ~ 2021.2.7 Handy sampling 1001 20.8 ± 2.8 225/776 Undergraduate Multiversity Depression, Anxiety HADS Questionnaire
Rogowska 2021 Poland 2020.3.30 ~ 2021.6.12 Handy sampling 1961 23.23 ± 3.16 841/1120

Undergraduate (1151)

Postgraduate (810)

Multiversity Anxiety, Pressure PSS-10, GAD-7 Questionnaire
Kristina 2021 Germany 2020.6.29 ~ 2020.7.26 Handy sampling 623  ≥ 18 514/109 Undergraduate Multiversity Pressure Self-made scale Questionnaire
Kezang 2022 Bhutan 2020.9.10 ~ 2020.10.10 Handy sampling 278 21.7 ± 2.07 194/84 Undergraduate Multiversity Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Biswas 2021 Bengal 2020.4.21 ~ 2020.5.10 Handy sampling 425 22.0 ± 1.8 160/265 Undergraduate Medical Depression PHQ-9 Questionnaire
Jesus 2021 Spain 2021.2.1 ~ 2021.3.15 Handy sampling 517 21.03 ± 4.32 409/108 Undergraduate Multiversity Anxiety, Fear, Pressure FCV-19S, GAD-7, BRCS Questionnaire
Adriana 2021 Brazil 2020.9.14 ~ 2020.10.19 Handy sampling 1224  ≥ 18 384/840 Undergraduate Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Sarah 2021 Uganda 2020.6.29 ~ 2020.7.29 Handy sampling 321 24.8 ± 5.1 198/123

Undergraduate (273)

Postgraduate (48)

Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Lucia 2021 Nigeria 2020.4.29 ~ 2020.5.5 Handy sampling 386 21.0. ± 2.9 154/232 Undergraduate Multiversity Depression, Anxiety HADS Questionnaire
Chootong 2022 Thailand 2021.9 ~ 2021.10 Handy sampling 325 21 ± 3 139/186 Undergraduate Medical Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Mai Sakai 2022 Japan 2020.8.18 ~ 2020.10.31 Handy sampling 281 18 ~ 22 43/238 Undergraduate Multiversity Depression, Anxiety HADS Questionnaire
Puteikis 2022 Lithuania 2021.10.20 ~ 2021.11.20 Handy sampling 628 16.1 ± 1.2 186/442 senior / Depression, Anxiety BDI, GAD-7, Questionnaire
Rasma 2022 Bengal 2020.5 ~ 2020.8 Handy sampling 605 23.1 ± 3.4 245/360

Undergraduate (431)

Postgraduate (174)

Multiversity Anxiety GAD-7 Questionnaire
Daniel 2022 Uganda 2021.6.26 ~ 2021.7.26 Handy sampling 338  ≥ 18 213/125

Undergraduate (288)

Postgraduate (50)

Multiversity Anxiety GAD-7 Questionnaire
Tiange Lu 2022 China 2020.3.19 ~ 2020.3.29 Handy sampling 795 17 ± 1.42 582/213 Senior / Depression, Anxiety SAS, SDS Questionnaire
Maria 2022 Mexico NR Handy sampling 252 21.12 ± 3.21 86/166 Undergraduate Multiversity Depression, Anxiety, Pressure DASS-21 Questionnaire
Mohammad 2022 Bengal 2021.1.7 ~ 2021.3.27 Handy sampling 731  ≥ 18 355/376 Undergraduate Medical Depression, Anxiety, Pressure DASS-21 Questionnaire
Scott 2021 America 2020.4.13 ~ 2020.4.28 Handy sampling 1428 22.3 ± 9.0 476/952

Undergraduate (1400)

Postgraduate (28)

Medical Depression, Anxiety PHQ-9, GAD-7 Questionnaire
Kyoko 2021 Japan 2020.5.20 ~ 2020.6.16 Handy sampling 2449 20.5 ± 3.5 1330/1119 Undergraduate Multiversity Depression PHQ-9 Questionnaire
Hakami 2021 Saudi Arabia 2020.4.14 ~ 2020.4.26 Handy sampling 697 21.76 ± 1.86 316/381 Undergraduate Medical Depression, Anxiety, Pressure DASS-21 Questionnaire
Thomas 2021 Switzerland 2020.3 ~ 2020.9 Handy sampling 3571 26.0 ± 5.5 1089/2482 Undergraduate Multiversity Depression PHQ-9 Questionnaire
Abdullah 2021 Saudi Arabia 2020.4.21 ~ 20,205.20 Random sampling 119 NR 101/18 Undergraduate Multiversity Anxiety GAD-7 Questionnaire
Benojir 2021 Bengal 2020.4.23 ~ 2020.4.30 Handy sampling 1317  ≥ 18 766/551

Undergraduate (846)

Postgraduate (471)

Multiversity Depression, Anxiety, Fear GAD-7, FCS-19S, WHO-5 Questionnaire
Beata 2022 Czech 2020.1 ~ 2020.6 Handy sampling 3099  ≥ 18 955/2144 Undergraduate Multiversity Depression, Anxiety PHQ-15, GAD-7 Questionnaire

SAS Self-rating anxiety scale, PHQ-9 Patient health questionnaire depression module-9, GAD-7 General anxiety disorder-7 item scale, SDS Self-rating depression scale, RQ-20 Relationship questionnaire-20, SSRS Social Support rating scale, SCARED The screen for child anxiety related emotional disorders, SRQ-20 Self-reporting questionnaire-20, HAMA Hamilton anxiety scale, DASS-21 Depression anxiety stress scale-21 item, SCL-90 Symptom checklist 90, PQEEPH Psychological questionnaires for emergent events of public health, ERQ Emotion regulation questionnaire, GPS-T Global pain scale-T, YBOCS Yale-brown obsessive–compulsive scale, CES-D Center for epidemiological survey-depression scale, IES-6 Impact of event scale-revised, CDI Children’s depression inventory, PHE-S Psychometric hepatic encephalopathy score, HADS Hospital anxiety and depression scale, FCV-19S Fear of COVID-19 scale, BDI Beck depression rating scale, / Not reported.