TABLE 1.
Participant demographic and IBS and GRS characteristics
| Results by population | Results by country | |||||
|---|---|---|---|---|---|---|
| Results expressed as mean ± SD (Min‐Max) or % | All (305) | General population (GPop) (119) | IBS (186) | UK (105) 39 GP/66 IBS | FR (100) 41 GP/59 IBS | SP (100) 39 GP/61 IBS |
| Women | 68.9% | 58.8% | 75.3% | 72.4% | 64% | 70% |
| Age (years) | 41.7 ± 13.6 (18‐74) | 44.1 ± 14 (19‐73) | 40.1 ± 13.1 (18‐74) | 39.7 ± 13.7 (19‐74) | 40.5 ± 13.3 (19 ‐72) | 44.9 ± 13.3 (18‐73) |
| BMI (score) | 24.2 ± 3.2 (16.8‐29.9) | 24.8 ± 3.1 (16.8a‐29.8) | 23.8 ± 3.1 (18.5‐29.9) | 24.6 ± 3 (18.9‐29.9) | 23.5 ± 3.4 (16.8‐29.8) | 24.5 ± 3.1 (18.7‐29.9) |
| Duration of GRS (years) | 8.4 ± 8.3 (0.2‐50)b | 8.3 ± 8.3 (0.2‐50) | 8.4 ± 8.3 (0.5‐50) | 10.6 ± 9.4 (1‐50) | 6.9 ± 7.6 (0.2‐50) | 7.5 ± 7.2 (0.5‐35) |
| Duration of IBS (years) | 9.3 ± 8.6 (0.5‐50) | 12.4 ± 9.9 (2‐50) | 7.3 ± 6.7 (1‐30) | 7.9 ± 7.8 (0.5‐35) | ||
| IBS Subtype | ||||||
| IBS‐C | 68 (36.6%) | 26 (39.4%) | 20 (33.9%) | 22 (36.1%) | ||
| IBS‐D | 61 (32.8%) | 19 (28.8%) | 23 (39.0%) | 19 (31.1%) | ||
| IBS‐M | 57 (30.6%) | 21 (31.8%) | 16 (27.1%) | 20 (32.8%) | ||
| IBS‐SSS (score) for IBS | 251.9 ± 41.2 (138‐303)d | 261.7 ± 40.2 (140‐300) | 248.8 ± 37.5 (138‐303)d | 244.3 ± 44.1 (146‐302)d | ||
| Number of bowel movements per week | ||||||
| IBS | 10.5 ± 9 (1‐50) | 12.1 ± 11.6 (1‐50) | 10 ± 7.5 (1‐42) | 9.3 ± 6.5 (1‐30) | ||
| GP | 8.9 ± 4.6 (3‐21) | 9 ± 4.5 (3‐21) | 9.7 ± 5.3 (3‐21) | 8.1 ± 3.9 (3‐21) | ||
| SST (score) | 14.4 ± 3.4 (5‐20) | 13.8 ± 3.5 (5‐20) | 14.9 ± 3.2 (6‐20) | 14.2 ± 3.2 (6‐20) | 15.1 ± 3.6 (6‐20) | 14 ± 3.3 (5‐20) |
| FDDQL (Global score) | 50.8 ± 16.9 (12.6‐92.9) | 59.3 ± 18.7 (12.6‐92.9) | 45.4 ± 13 (15.6‐77.1) | 57.4 ± 18.6 (19.2‐92.6) | 43.9 ± 14.4 (12.6‐92.9) | 50.9 ± 14.4 (21.3‐79.7) |
| EQ‐5D Index | 0.75 ± 0.20 (0.1‐1)c | 0.80 ± 0.20 (0.12‐1) | 0.72 ± 0.19 (0.12‐1) | 0.81 ± 0.16 (0.25‐1) | 0.62 ± 0.23 (0.12‐1) | 0.81 ± 0.14 (0.33‐1) |
Abbreviations: BMI, Body Mass Index; FDDQL, Functional Digestive Disorders Quality of Life; GRS, Gas‐Related Symptoms; IBS, Irritable Bowel Syndrome; IBS‐SSS, Irritable Bowel Syndrome Severity Scoring System; SST, Symptom Screening Tool.
a
1 subject had a BMI inferior to the threshold 18.5 requested by the protocol.
b
n = 304.
c
n = 303.
d
2 patients had a IBS‐SSS just over 300.