FIGURE 3.

Plasma concentrations of FGF21 and corticosterone after social defeat stress. Plasma FGF21 concentrations after social defeat stress and plasma corticosterone concentrations after social defeat stress are shown. Mice received 10 minutes of social defeat stress once per day. Plasma concentrations 24 hour after the fourth social defeat stress (0) and 30 min (30), 60 min (60) and 120 min (120) after initiation of the fifth social defeat stress were determined. Non‐stress rats were placed in a test cage but received no social defeat stress. Plasma FGF21 concentrations were significantly higher in the social defeat stress group compared to the non‐stress group. Plasma corticosterone concentrations were significantly higher after social defeat stress compared to the concentrations in the non‐stress group and those before social defeat stress. The number of animals in each group was 10. †P < 0.05 (left), social defeat stress vs non‐stress, two‐way factorial ANOVA. *P < 0.05, ****P < 0.0001, stress group vs non‐stress group at corresponding time points; ##P < 0.01 vs after the fifth stress (30 min), ####P < 0.0001 vs before the fifth stress (0 min) in the stress group, two‐way factorial ANOVA followed by Bonferroni's test